Abstract：
Antibiotics, their transformation products, and the translocation of antibiotic-resistant genes in the environment pose significant health risks to humans, animals, and ecosystems, aligning with the One Health concept. Constructed wetlands hold substantial yet underutilized potential for treating wastewater from agricultural, domestic sewage, or contaminated effluents from wastewater treatment plants, with the goal of eliminating antibiotics. However, the comprehensive understanding of the distribution, persistence, and dissipation processes of antibiotics within constructed wetlands remains largely unexplored. In this context, we provide an overview of the current application of stable isotope analysis at natural abundance to antibiotics. We explore the opportunities of an advanced multiple stable isotope approach, where isotope concepts could be effectively applied to examine the fate of antibiotics in wetlands. The development of a conceptual framework to study antibiotics in wetlands using multi-element stable isotopes introduces a new paradigm, offering enhanced insights into the identification and quantification of natural attenuation of antibiotics within wetland systems. This perspective has the potential to inspire the general public, governmental bodies, and the broader research community, fostering an emphasis on the utilization of stable isotope analysis for studying antibiotics and other emerging micropollutants in wetland systems.
摘要：
抗生素,他们的转型产品，抗生素抗性基因在环境中的易位给人类带来了巨大的健康风险，动物,和生态系统，与“一个健康”概念保持一致。人工湿地具有处理农业废水的巨大潜力，但未得到充分利用。生活污水,或污水处理厂的污染废水，以消除抗生素为目标。然而,对分布的全面了解，持久性,抗生素在人工湿地内的消散过程仍未被探索。在这种情况下，我们概述了在自然丰度下稳定同位素分析在抗生素中的当前应用。我们探索先进的多稳定同位素方法的机会，同位素概念可以有效地应用于检查湿地中抗生素的命运。使用多元素稳定同位素研究湿地抗生素的概念框架的发展引入了一种新的范式，为湿地系统中抗生素自然衰减的识别和量化提供了更深入的见解。这种观点有可能激励广大市民,政府机构,以及更广泛的研究团体，强调利用稳定同位素分析来研究湿地系统中的抗生素和其他新兴微污染物。
