Abstract：
Fatigue is a common physiological state that affects normal human activities. Prolonged fatigue induces a variety of diseases and seriously affects human health, so it is imperative to discover nutritional dietary supplements and treatments without side effects, among which natural anti-fatigue polysaccharides have shown great potential. Polysaccharides, a class of biomolecules produced by a variety of organisms such as plants, animals, bacteria and algae, have attracted much attention in recent years due to their anti-fatigue activity and fewer side effects. This review summarizes the classification, dosage and experimental models of polysaccharides with anti-fatigue activity obtained from different natural sources. We also review the fatigue-relieving effects of these polysaccharides through mechanisms such as modulating oxidative damage, regulating energy metabolism and influencing intestinal flora, as well as the effects of molecular weights, monosaccharide compositions, structural features and chemical modifications of the polysaccharides on their anti-fatigue activities to support their potential application value in functional foods and pharmaceuticals. New valuable insights for future research on natural polysaccharides are also presented in the field of natural production of bio-based functional materials, functional foods and therapeutic agents.
摘要：
疲劳是影响人类正常活动的常见生理状态。长时间的疲劳会诱发多种疾病,严重影响人类健康,因此，必须发现没有副作用的营养膳食补充剂和治疗方法，其中天然抗疲劳多糖显示出巨大的潜力。多糖，由植物等多种生物产生的一类生物分子，动物,细菌和藻类，近年来由于其抗疲劳活性和较少的副作用而备受关注。这篇综述总结了分类，从不同天然来源获得的具有抗疲劳活性的多糖的剂量和实验模型。我们还回顾了这些多糖通过调节氧化损伤等机制缓解疲劳的作用，调节能量代谢，影响肠道菌群，以及分子量的影响，单糖组合物，多糖的结构特征和化学修饰对其抗疲劳活性的影响，支持其在功能性食品和药物中的潜在应用价值。在生物基功能材料的自然生产领域也提出了对未来天然多糖研究的新的有价值的见解，功能性食品和治疗剂。
