Abstract：
Short-term exposure to ozone has been linked to multiple allergic diseases, but the relationship between ozone exposure and allergic conjunctivitis (AC) remains unclear. This study aimed to investigate the association between short-term exposure to ozone and the risk of AC. We conducted a time-stratified case-crossover study across five Chinese cities from 2014 to 2022. Daily outpatient visit records for AC were identified in five hospitals using either the diagnosis name or ICD-10 code H10.1. Data on air pollution and meteorological conditions were also collected. We first examined the city-specific association between short-term ozone exposure and AC using conditional logistic regression. A random-effects meta-analysis was then conducted to obtain overall estimates. During the study period, 130,093 outpatient visits for AC occurred, with 58.8% (76,482) being male and 41.2% (53,611) female. A one-standard-deviation (SD) increase in ozone was associated with an 8.3% increase (95% CI: 3.8%, 13.0%) in AC outpatient visits. Similar positive associations were observed when adjusting for other pollutants (PM2.5, CO, SO2 and NO2) in two-pollutant and multi-pollutant models. Furthermore, the positive association remained consistent when using mixed-effects regression models or further adjusting for meteorological conditions. In addition, no effect modification of the AC-ozone association by sex, age and season was apparent. This study provides evidence supporting a positive association between short-term ozone exposure and AC risk in China. This highlights the potential value of mitigating ozone pollution to reduce the risk of ocular surface disorders.
摘要：
短期接触臭氧与多种过敏性疾病有关，但臭氧暴露与过敏性结膜炎（AC）之间的关系尚不清楚。本研究旨在探讨短期臭氧暴露与AC风险之间的关系。从2014年到2022年，我们在中国五个城市进行了时间分层的病例交叉研究。使用诊断名称或ICD-10代码H10.1在五家医院中确定了AC的每日门诊就诊记录。还收集了有关空气污染和气象条件的数据。我们首先使用条件逻辑回归检查了短期臭氧暴露与AC之间特定城市的关联。然后进行随机效应荟萃分析以获得总体估计。在学习期间,发生了130,093次AC门诊就诊，男性占58.8%(76,482)，女性占41.2%(53,611)。臭氧的一个标准偏差（SD）增加与8.3％的增加有关（95％CI：3.8％，13.0%)在AC门诊就诊。在调整其他污染物(PM2.5、CO、SO2和NO2）在双污染物和多污染物模型中。此外，当使用混合效应回归模型或进一步调整风速时,正相关保持一致.此外,按性别对交流臭氧协会没有影响，年龄和季节很明显。这项研究提供了支持短期臭氧暴露与中国AC风险之间正相关的证据。这凸显了减轻臭氧污染以降低眼表疾病风险的潜在价值。
