Abstract：
Medical applications of iridium (III) complexes include their use as state-of-the-art theranostic agents - molecules that combine therapeutic and diagnostic functions into a single entity. These complexes offer a promising avenue in medical diagnostics, precision imaging at single-cell resolution and targeted anticancer therapy due to their unique properties. In this review we report a short summary of their application in medical diagnostics, imaging at single-cell level and targeted anticancer therapy. The exceptional photophysical properties of Iridium (III) complexes, including their brightness and photostability, make them excellent candidates for bioimaging. They can be used to image cellular processes and the microenvironment within single cells with unprecedented clarity, aiding in the understanding of disease mechanisms at the molecular level. Moreover the iridium (III) complexes can be designed to selectively target cancer cells,. Upon targeting, these complexes can act as photosensitizers for photodynamic therapy (PDT), generating reactive oxygen species (ROS) upon light activation to induce cell death. The integration of diagnostic and therapeutic capabilities in Iridium (III) complexes offers the potential for a holistic approach to cancer treatment, enabling not only the precise eradication of cancer cells but also the real-time monitoring of treatment efficacy and disease progression. This aligns with the goals of personalized medicine, offering hope for more effective and less invasive cancer treatment strategies.
摘要：
铱（III）配合物的医学应用包括它们作为最先进的治疗药物的用途-将治疗和诊断功能结合成单一实体的分子。这些复合物为医学诊断提供了一个有希望的途径，精确成像在单细胞分辨率和靶向抗癌治疗由于其独特的性质。在这篇综述中，我们报告了它们在医学诊断中的应用，在单细胞水平成像和靶向抗癌治疗。铱（III）配合物的特殊光物理性质，包括它们的亮度和光稳定性，使他们成为生物成像的优秀候选人。它们可用于以前所未有的清晰度对单细胞内的细胞过程和微环境进行成像。有助于在分子水平上理解疾病机制。此外，铱（III）络合物可以被设计为选择性靶向癌细胞，.瞄准时，这些复合物可以作为光动力疗法（PDT）的光敏剂，光激活后产生活性氧（ROS）以诱导细胞死亡。铱（III）复合物的诊断和治疗能力的整合为癌症治疗的整体方法提供了潜力，不仅可以精确根除癌细胞，还可以实时监测治疗效果和疾病进展。这符合个性化医疗的目标，为更有效和侵入性较小的癌症治疗策略提供了希望。
