PDF(Pubmed)
Abstract：
BACKGROUND: Diabetes mellitus (DM) is well known for related micro and macrovascular complications. Uncontrolled hyperglycemia in diabetes mellitus leads to endothelial dysfunction, inflammation, microvascular impairment, myocardial dysfunction, and skeletal muscle changes which affect multiple organ systems. This study was designed to take an extensive view of cardiorespiratory dynamics in patients with type 2 DM.
METHODS: One hundred healthy controls (HC) and 100 DM patients were enrolled. We measured and compared the breathing patterns (spirometry), VO2 max levels (heart rate ratio method) and self-reported fitness level (international fitness scale) of individuals with and without diabetes. Data was analyzed in SPSS v.22 and GraphPad Prism v8.0.
RESULTS: We observed restrictive spirometry patterns (FVC <80%) in 22% of DM as compared to 2% in HC (p = 0.021). There was low mean VO2 max in DM as compared to HC(32.03 ± 5.36 vs 41.91 ± 7.98 ml/kg/min; p value <0.001). When evaluating physical fitness on self-reported IFiS scale, 90% of the HC report average, good, or very good fitness levels. In contrast, only 45% of the DM shared this pattern, with a 53% proportion perceiving their fitness as poor or very poor (p = <0.05). Restrictive respiratory pattern, low VO2 max and fitness level were significantly associated with HbA1c and long-standing DM.
CONCLUSIONS: This study shows decreased pulmonary functions, decreased cardiorespiratory fitness (VO2 max) and IFiS scale variables in diabetic population as compared to healthy controls which are also associated with glycemic levels and long-standing DM. Screening for pulmonary functions can aid optimum management in this population.
METHODS: One hundred healthy controls (HC) and 100 DM patients were enrolled. We measured and compared the breathing patterns (spirometry), VO2 max levels (heart rate ratio method) and self-reported fitness level (international fitness scale) of individuals with and without diabetes. Data was analyzed in SPSS v.22 and GraphPad Prism v8.0.
RESULTS: We observed restrictive spirometry patterns (FVC <80%) in 22% of DM as compared to 2% in HC (p = 0.021). There was low mean VO2 max in DM as compared to HC(32.03 ± 5.36 vs 41.91 ± 7.98 ml/kg/min; p value <0.001). When evaluating physical fitness on self-reported IFiS scale, 90% of the HC report average, good, or very good fitness levels. In contrast, only 45% of the DM shared this pattern, with a 53% proportion perceiving their fitness as poor or very poor (p = <0.05). Restrictive respiratory pattern, low VO2 max and fitness level were significantly associated with HbA1c and long-standing DM.
CONCLUSIONS: This study shows decreased pulmonary functions, decreased cardiorespiratory fitness (VO2 max) and IFiS scale variables in diabetic population as compared to healthy controls which are also associated with glycemic levels and long-standing DM. Screening for pulmonary functions can aid optimum management in this population.
摘要：
背景：糖尿病（DM）是众所周知的相关微血管和大血管并发症。糖尿病患者不受控制的高血糖会导致内皮功能障碍,炎症,微血管损伤，心肌功能障碍,和影响多器官系统的骨骼肌变化。这项研究旨在对2型DM患者的心肺动力学进行广泛研究。
方法：纳入100名健康对照（HC）和100名DM患者。我们测量并比较了呼吸模式（肺活量测定），有和没有糖尿病的个体的VO2最大水平（心率比法）和自我报告的健康水平（国际健康量表）。在SPSSv.22和GraphPadPrismv8.0中分析数据。
结果：我们在22%的DM中观察到限制性肺活量测定模式（FVC<80%），而在HC中为2%（p=0.021）。与HC相比，DM的平均VO2max较低（32.03±5.36vs41.91±7.98ml/kg/min；p值<0.001）。在自我报告的IFIS量表上评估身体健康时，HC报告平均值的90%，不错,或者非常好的健身水平。相比之下,只有45%的DM共享这种模式，53%的人认为他们的健康状况很差或非常差(p=<0.05)。限制性呼吸模式，低VO2max和健康水平与HbA1c和长期DM显著相关.
结论：这项研究显示肺功能下降，与健康对照组相比，糖尿病人群的心肺适应性（VO2max）和IFiS量表变量降低，这也与血糖水平和长期DM相关。筛查肺功能可以帮助该人群的最佳管理。
方法：纳入100名健康对照（HC）和100名DM患者。我们测量并比较了呼吸模式（肺活量测定），有和没有糖尿病的个体的VO2最大水平（心率比法）和自我报告的健康水平（国际健康量表）。在SPSSv.22和GraphPadPrismv8.0中分析数据。
结果：我们在22%的DM中观察到限制性肺活量测定模式（FVC<80%），而在HC中为2%（p=0.021）。与HC相比，DM的平均VO2max较低（32.03±5.36vs41.91±7.98ml/kg/min；p值<0.001）。在自我报告的IFIS量表上评估身体健康时，HC报告平均值的90%，不错,或者非常好的健身水平。相比之下,只有45%的DM共享这种模式，53%的人认为他们的健康状况很差或非常差(p=<0.05)。限制性呼吸模式，低VO2max和健康水平与HbA1c和长期DM显著相关.
结论：这项研究显示肺功能下降，与健康对照组相比，糖尿病人群的心肺适应性（VO2max）和IFiS量表变量降低，这也与血糖水平和长期DM相关。筛查肺功能可以帮助该人群的最佳管理。
