Abstract：
OBJECTIVE: T1 mapping and T1-weighted contrasts have a complimentary but currently under utilized role in fetal MRI. Emerging clinical low field scanners are ideally suited for fetal T1 mapping. The advantages are lower T1 values which results in higher efficiency and reduced field inhomogeneities resulting in a decreased requirement for specialist tools. In addition the increased bore size associated with low field scanners provides improved patient comfort and accessibility. This study aims to demonstrate the feasibility of fetal brain T1 mapping at 0.55T.
METHODS: An efficient slice-shuffling inversion-recovery echo-planar imaging (EPI)-based T1-mapping and postprocessing was demonstrated for the fetal brain at 0.55T in a cohort of 38 fetal MRI scans. Robustness analysis was performed and placental measurements were taken for validation.
RESULTS: High-quality T1 maps allowing the investigation of subregions in the brain were obtained and significant correlation with gestational age was demonstrated for fetal brain T1 maps ( p < 0 . 05 $$ p<0.05 $$ ) as well as regions-of-interest in the deep gray matter and white matter.
CONCLUSIONS: Efficient, quantitative T1 mapping in the fetal brain was demonstrated on a clinical 0.55T MRI scanner, providing foundations for both future research and clinical applications including low-field specific T1-weighted acquisitions.
METHODS: An efficient slice-shuffling inversion-recovery echo-planar imaging (EPI)-based T1-mapping and postprocessing was demonstrated for the fetal brain at 0.55T in a cohort of 38 fetal MRI scans. Robustness analysis was performed and placental measurements were taken for validation.
RESULTS: High-quality T1 maps allowing the investigation of subregions in the brain were obtained and significant correlation with gestational age was demonstrated for fetal brain T1 maps ( p < 0 . 05 $$ p<0.05 $$ ) as well as regions-of-interest in the deep gray matter and white matter.
CONCLUSIONS: Efficient, quantitative T1 mapping in the fetal brain was demonstrated on a clinical 0.55T MRI scanner, providing foundations for both future research and clinical applications including low-field specific T1-weighted acquisitions.
摘要：
目的：T1标测和T1加权对比在胎儿MRI中具有互补但目前尚未被利用的作用。新兴的临床低场扫描仪非常适合胎儿T1标测。优点是较低的T1值，这导致更高的效率和减少的场不均匀性，从而降低了对专用工具的需求。此外,与低场扫描仪相关联的增加的孔尺寸提供了改善的患者舒适度和可接近性。本研究旨在证明胎儿脑T1标测在0.55T的可行性。
方法：在一组38例胎儿MRI扫描中，在0.55T的胎儿大脑中，证明了一种有效的基于切片混洗反转恢复回波平面成像（EPI）的T1映射和后处理。进行稳健性分析，并进行胎盘测量以进行验证。
结果：获得了高质量的T1图，可以对大脑中的子区域进行调查，并证明了胎儿大脑T1图与胎龄的显着相关性（p<0。05$$p<0.05$$）以及深灰质和白质中的感兴趣区域。
结论：高效，在临床0.55TMRI扫描仪上证明了胎儿大脑中的定量T1映射，为未来的研究和临床应用提供基础，包括低领域特定的T1加权收购。
方法：在一组38例胎儿MRI扫描中，在0.55T的胎儿大脑中，证明了一种有效的基于切片混洗反转恢复回波平面成像（EPI）的T1映射和后处理。进行稳健性分析，并进行胎盘测量以进行验证。
结果：获得了高质量的T1图，可以对大脑中的子区域进行调查，并证明了胎儿大脑T1图与胎龄的显着相关性（p<0。05$$p<0.05$$）以及深灰质和白质中的感兴趣区域。
结论：高效，在临床0.55TMRI扫描仪上证明了胎儿大脑中的定量T1映射，为未来的研究和临床应用提供基础，包括低领域特定的T1加权收购。
