METHODS: An efficient slice-shuffling inversion-recovery echo-planar imaging (EPI)-based T1-mapping and postprocessing was demonstrated for the fetal brain at 0.55T in a cohort of 38 fetal MRI scans. Robustness analysis was performed and placental measurements were taken for validation.
RESULTS: High-quality T1 maps allowing the investigation of subregions in the brain were obtained and significant correlation with gestational age was demonstrated for fetal brain T1 maps ( p < 0 . 05 $$ p<0.05 $$ ) as well as regions-of-interest in the deep gray matter and white matter.
CONCLUSIONS: Efficient, quantitative T1 mapping in the fetal brain was demonstrated on a clinical 0.55T MRI scanner, providing foundations for both future research and clinical applications including low-field specific T1-weighted acquisitions.
方法:在一组38例胎儿MRI扫描中,在0.55T的胎儿大脑中,证明了一种有效的基于切片混洗反转恢复回波平面成像(EPI)的T1映射和后处理。进行稳健性分析,并进行胎盘测量以进行验证。
结果:获得了高质量的T1图,可以对大脑中的子区域进行调查,并证明了胎儿大脑T1图与胎龄的显着相关性(p<0。05$$p<0.05$$)以及深灰质和白质中的感兴趣区域。
结论:高效,在临床0.55TMRI扫描仪上证明了胎儿大脑中的定量T1映射,为未来的研究和临床应用提供基础,包括低领域特定的T1加权收购。