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Abstract：
Glioma is the most common malignant tumor in the central nervous system, and its unique pathogenesis often leads to poor treatment outcomes and prognosis. In 2021, the World Health Organization (WHO) divided gliomas into five categories based on their histological characteristics and molecular changes. Non-coding RNA is a type of RNA that does not encode proteins but can exert biological functions at the RNA level, and long non-coding RNA (lncRNA) is a type of non-coding RNA with a length exceeding 200 nt. It is controlled by various transcription factors and plays an indispensable role in the regulatory processes in various cells. Numerous studies have confirmed that the dysregulation of lncRNA is critical in the pathogenesis, progression, and malignancy of gliomas. Therefore, this article reviews the proliferation, apoptosis, invasion, migration, angiogenesis, immune regulation, glycolysis, stemness, and drug resistance changes caused by the dysregulation of lncRNA in gliomas, and summarizes their potential clinical significance in gliomas.
摘要：
胶质瘤是中枢神经系统最常见的恶性肿瘤，其独特的发病机制往往导致不良的治疗效果和预后。2021年，世界卫生组织（WHO）根据胶质瘤的组织学特征和分子变化将其分为五类。非编码RNA是一类不编码蛋白质但能在RNA水平上发挥生物学功能的RNA。长非编码RNA(lncRNA)是一种长度超过200nt的非编码RNA。它受各种转录因子的控制，在各种细胞的调节过程中起着不可或缺的作用。许多研究已经证实lncRNA的失调在发病机制中至关重要。programming,和恶性胶质瘤。因此,这篇文章回顾了扩散，凋亡，入侵,迁移,血管生成,免疫调节，糖酵解,stemness,和由神经胶质瘤中lncRNA失调引起的耐药性变化，并总结了它们在神经胶质瘤中的潜在临床意义。
