PDF(Pubmed)
Abstract：
Considering the biological activity of osteoblasts is crucial when devising new approaches to enhance the osseointegration of implant surfaces, as their behavior profoundly influences clinical outcomes. An established inverse correlation exists between osteoblast proliferation and their functional differentiation, which constrains the rapid generation of a significant amount of bone. Examining the surface morphology of implants reveals that roughened titanium surfaces facilitate rapid but thin bone formation, whereas smooth, machined surfaces promote greater volumes of bone formation albeit at a slower pace. Consequently, osteoblasts differentiate faster on roughened surfaces but at the expense of proliferation speed. Moreover, the attachment and initial spreading behavior of osteoblasts are notably compromised on microrough surfaces. This review delves into our current understanding and recent advances in nanonodular texturing, meso-scale texturing, and UV photofunctionalization as potential strategies to address the \"biological dilemma\" of osteoblast kinetics, aiming to improve the quality and quantity of osseointegration. We discuss how these topographical and physicochemical strategies effectively mitigate and even overcome the dichotomy of osteoblast behavior and the biological challenges posed by microrough surfaces. Indeed, surfaces modified with these strategies exhibit enhanced recruitment, attachment, spread, and proliferation of osteoblasts compared to smooth surfaces, while maintaining or amplifying the inherent advantage of cell differentiation. These technology platforms suggest promising avenues for the development of future implants.
摘要：
考虑到成骨细胞的生物活性是至关重要的，当设计新的方法来增强植入物表面的骨整合，因为他们的行为会深刻影响临床结果。成骨细胞增殖和它们的功能分化之间存在着明显的负相关,这限制了大量骨骼的快速生成。检查植入物的表面形态表明，粗糙的钛表面促进快速但薄的骨形成，而光滑，加工表面促进更大量的骨形成，虽然在一个较慢的速度。因此,成骨细胞在粗糙表面上分化更快，但以增殖速度为代价。此外，成骨细胞的附着和初始扩散行为在微粗糙表面上明显受损。这篇综述深入探讨了我们目前对纳米节点纹理的理解和最新进展，中尺度纹理，和紫外光功能化作为解决成骨细胞动力学的“生物学困境”的潜在策略，旨在提高骨整合的质量和数量。我们讨论了这些地形和物理化学策略如何有效地减轻甚至克服成骨细胞行为的二分法以及微粗糙表面带来的生物学挑战。的确,用这些策略修改的表面表现出增强的招募，附件,传播，与光滑表面相比，成骨细胞的增殖，同时保持或放大细胞分化的固有优势。这些技术平台为未来植入物的发展提供了有希望的途径。
