PDF(Pubmed)
Abstract：
UNASSIGNED: Health-related quality of life (QoL) impairment is common after pulmonary embolism (PE). Whether the severity of the initial PE has an impact on QoL is unknown.
UNASSIGNED: To evaluate the association between severity of PE and QoL over time.
UNASSIGNED: We prospectively assessed PE-specific QoL using the Pulmonary Embolism Quality of Life (lower scores indicate better QoL) questionnaire and generic QoL using the Short Form 36 (higher scores indicate better QoL) questionnaire at baseline and 3 and 12 months in older patients with acute PE. We examined whether QoL differed by PE severity based on hemodynamic status, simplified Pulmonary Embolism Severity Index (sPESI), right ventricular function, and high-sensitivity troponin T in mixed-effects models, adjusting for known QoL predictors after PE.
UNASSIGNED: Among 546 patients with PE (median age, 74 years), severe vs nonsevere PE based on the sPESI was associated with a worse PE-specific (adjusted mean Pulmonary Embolism Quality of Life score difference of 6.1 [95% CI, 2.4-9.8] at baseline, 7.6 [95% CI, 4.0-11.3] at 3 months, and 6.7 [95% CI, 2.9-10.4] at 12 months) and physical generic QoL (adjusted mean Short Form 36 Physical Component Summary score difference of -3.8 [95% CI, -5.5 to -2.1] at baseline, -4.8 [95% CI, -6.4 to -3.1] at 3 months, and -4.1 [95% CI, -5.8 to -2.3] at 12 months). Elevated troponin levels were also associated with lower PE-specific QoL at 3 months and lower physical generic QoL at 3 and 12 months. QoL did not differ by hemodynamic status or right ventricular function.
UNASSIGNED: Severe PE based on the sPESI was consistently associated with worse PE-specific and physical generic QoL over time as compared to nonsevere PE.
UNASSIGNED: To evaluate the association between severity of PE and QoL over time.
UNASSIGNED: We prospectively assessed PE-specific QoL using the Pulmonary Embolism Quality of Life (lower scores indicate better QoL) questionnaire and generic QoL using the Short Form 36 (higher scores indicate better QoL) questionnaire at baseline and 3 and 12 months in older patients with acute PE. We examined whether QoL differed by PE severity based on hemodynamic status, simplified Pulmonary Embolism Severity Index (sPESI), right ventricular function, and high-sensitivity troponin T in mixed-effects models, adjusting for known QoL predictors after PE.
UNASSIGNED: Among 546 patients with PE (median age, 74 years), severe vs nonsevere PE based on the sPESI was associated with a worse PE-specific (adjusted mean Pulmonary Embolism Quality of Life score difference of 6.1 [95% CI, 2.4-9.8] at baseline, 7.6 [95% CI, 4.0-11.3] at 3 months, and 6.7 [95% CI, 2.9-10.4] at 12 months) and physical generic QoL (adjusted mean Short Form 36 Physical Component Summary score difference of -3.8 [95% CI, -5.5 to -2.1] at baseline, -4.8 [95% CI, -6.4 to -3.1] at 3 months, and -4.1 [95% CI, -5.8 to -2.3] at 12 months). Elevated troponin levels were also associated with lower PE-specific QoL at 3 months and lower physical generic QoL at 3 and 12 months. QoL did not differ by hemodynamic status or right ventricular function.
UNASSIGNED: Severe PE based on the sPESI was consistently associated with worse PE-specific and physical generic QoL over time as compared to nonsevere PE.
摘要：
■肺栓塞（PE）后，与健康相关的生活质量（QoL）受损很常见。初始PE的严重程度是否对QoL有影响尚不清楚。
■评估PE的严重程度与QoL之间的相关性。
我们使用肺栓塞生活质量（得分较低表示QoL较好）问卷和使用简短表格36（得分较高表示QoL较好）问卷在基线和3个月和12个月老年急性PE患者中前瞻性评估PE特异性QoL。我们根据血流动力学状态检查了QoL是否因PE严重程度而有所不同，简化肺栓塞严重程度指数(sPESI)右心室功能,和混合效应模型中的高灵敏度肌钙蛋白T，调整PE后已知的QoL预测因子。
■在546例PE患者中（中位年龄，74年),基于sPESI的重度与非重度PE与较差的PE特异性相关(基线时校正平均肺栓塞生活质量评分差异为6.1[95%CI,2.4-9.8],3个月时7.6[95%CI，4.0-11.3]，和12个月时的6.7[95％CI，2.9-10.4]）和身体通用QoL（基线时调整后的平均简短表格36身体成分汇总得分差异为-3.8[95％CI，-5.5至-2.1]，3个月时-4.8[95%CI，-6.4至-3.1]，12个月时为-4.1[95%CI，-5.8至-2.3]）。肌钙蛋白水平的升高也与3个月时PE特异性QoL的降低和3个月和12个月时身体一般QoL的降低相关。QoL在血流动力学状态或右心室功能方面没有差异。
■与非严重PE相比，基于sPESI的严重PE与一段时间内较差的PE特异性和身体通用QoL始终相关。
■评估PE的严重程度与QoL之间的相关性。
我们使用肺栓塞生活质量（得分较低表示QoL较好）问卷和使用简短表格36（得分较高表示QoL较好）问卷在基线和3个月和12个月老年急性PE患者中前瞻性评估PE特异性QoL。我们根据血流动力学状态检查了QoL是否因PE严重程度而有所不同，简化肺栓塞严重程度指数(sPESI)右心室功能,和混合效应模型中的高灵敏度肌钙蛋白T，调整PE后已知的QoL预测因子。
■在546例PE患者中（中位年龄，74年),基于sPESI的重度与非重度PE与较差的PE特异性相关(基线时校正平均肺栓塞生活质量评分差异为6.1[95%CI,2.4-9.8],3个月时7.6[95%CI，4.0-11.3]，和12个月时的6.7[95％CI，2.9-10.4]）和身体通用QoL（基线时调整后的平均简短表格36身体成分汇总得分差异为-3.8[95％CI，-5.5至-2.1]，3个月时-4.8[95%CI，-6.4至-3.1]，12个月时为-4.1[95%CI，-5.8至-2.3]）。肌钙蛋白水平的升高也与3个月时PE特异性QoL的降低和3个月和12个月时身体一般QoL的降低相关。QoL在血流动力学状态或右心室功能方面没有差异。
■与非严重PE相比，基于sPESI的严重PE与一段时间内较差的PE特异性和身体通用QoL始终相关。
