PDF(Pubmed)
Abstract：
UNASSIGNED: Acute kidney injury (AKI) is a prevalent complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and a predictor of disease severity and mortality; furthermore, a prompt diagnosis and treatment of this complication may enhance COVID-19 prognosis. Therefore, we aim to investigate potential risk factors for SARS-CoV-2-associated AKI, including SARS-CoV-2 PCR cycle threshold value (CT value), which correlation with AKI is conflicting.
UNASSIGNED: This case-control study included 110 hospitalized patients with SARS-CoV-2-associated AKI as cases and 110 random SARS-CoV-2 hospitalized patients as controls. Reverse transcription real-time PCR of admission nasopharyngeal swabs evaluated E gene cycle thresholds. Additional clinical and paraclinical information extracted from medical records. The patient\'s status at discharge, and 14 and 30 days after discharge. Therefore, after adjusting for age and gender, the correlation between variables was assessed.
UNASSIGNED: SARS-CoV-2 AKI is significantly associated with age above 60, hypertension, diabetes mellitus, ischemic heart disease, and underlying kidney diseases. Abnormal admission hemoglobin or alkaline phosphatase, proteinuria or hematuria in urine sediment, and abnormal creatinine during hospitalization were the paraclinical features correlated to SARS-CoV-2 AKI. AKI group demonstrated greater in-hospital, 14- and 30-day mortality. Nevertheless, this study did not evidence a correlation between the admission CT value and mortality or AKI.
UNASSIGNED: Admission CT values provide limited information regarding the dynamic viral load and varying hospitalization time points; thus, they may not be reliable for predicting the prognosis and complications of COVID-19 in all populations. Further studies with serial CT measurements or symptom onset time adjustment are recommended.
UNASSIGNED: This case-control study included 110 hospitalized patients with SARS-CoV-2-associated AKI as cases and 110 random SARS-CoV-2 hospitalized patients as controls. Reverse transcription real-time PCR of admission nasopharyngeal swabs evaluated E gene cycle thresholds. Additional clinical and paraclinical information extracted from medical records. The patient\'s status at discharge, and 14 and 30 days after discharge. Therefore, after adjusting for age and gender, the correlation between variables was assessed.
UNASSIGNED: SARS-CoV-2 AKI is significantly associated with age above 60, hypertension, diabetes mellitus, ischemic heart disease, and underlying kidney diseases. Abnormal admission hemoglobin or alkaline phosphatase, proteinuria or hematuria in urine sediment, and abnormal creatinine during hospitalization were the paraclinical features correlated to SARS-CoV-2 AKI. AKI group demonstrated greater in-hospital, 14- and 30-day mortality. Nevertheless, this study did not evidence a correlation between the admission CT value and mortality or AKI.
UNASSIGNED: Admission CT values provide limited information regarding the dynamic viral load and varying hospitalization time points; thus, they may not be reliable for predicting the prognosis and complications of COVID-19 in all populations. Further studies with serial CT measurements or symptom onset time adjustment are recommended.
摘要：
■急性肾损伤（AKI）是严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）感染的普遍并发症，以及疾病严重程度和死亡率的预测指标；此外，这种并发症的及时诊断和治疗可能会提高COVID-19的预后.因此,我们的目的是调查SARS-CoV-2相关AKI的潜在危险因素，包括SARS-CoV-2PCR循环阈值（CT值），与AKI的相关性是矛盾的。
■本病例对照研究包括110例SARS-CoV-2相关AKI住院患者作为病例，110例SARS-CoV-2随机住院患者作为对照。入院鼻咽拭子的逆转录实时PCR评估E基因周期阈值。从医疗记录中提取的其他临床和临床旁信息。病人出院时的状况,出院后14天和30天。因此,在调整了年龄和性别后，评估变量之间的相关性.
■SARS-CoV-2AKI与60岁以上，高血压，糖尿病,缺血性心脏病,和潜在的肾脏疾病。入院血红蛋白或碱性磷酸酶异常，尿沉渣中的蛋白尿或血尿，住院期间肌酐异常是与SARS-CoV-2AKI相关的副临床特征。AKI组表现出更大的住院时间，14天和30天死亡率。然而，这项研究没有证据表明入院CT值与死亡率或AKI之间存在相关性.
■入院CT值提供了有关动态病毒载量和不同住院时间点的有限信息；因此，它们可能无法可靠地预测所有人群中COVID-19的预后和并发症.建议通过连续CT测量或症状发作时间调整进行进一步研究。
■本病例对照研究包括110例SARS-CoV-2相关AKI住院患者作为病例，110例SARS-CoV-2随机住院患者作为对照。入院鼻咽拭子的逆转录实时PCR评估E基因周期阈值。从医疗记录中提取的其他临床和临床旁信息。病人出院时的状况,出院后14天和30天。因此,在调整了年龄和性别后，评估变量之间的相关性.
■SARS-CoV-2AKI与60岁以上，高血压，糖尿病,缺血性心脏病,和潜在的肾脏疾病。入院血红蛋白或碱性磷酸酶异常，尿沉渣中的蛋白尿或血尿，住院期间肌酐异常是与SARS-CoV-2AKI相关的副临床特征。AKI组表现出更大的住院时间，14天和30天死亡率。然而，这项研究没有证据表明入院CT值与死亡率或AKI之间存在相关性.
■入院CT值提供了有关动态病毒载量和不同住院时间点的有限信息；因此，它们可能无法可靠地预测所有人群中COVID-19的预后和并发症.建议通过连续CT测量或症状发作时间调整进行进一步研究。
