Abstract：
Low levels of high-density lipoprotein (HDL) and impaired HDL functionality have been consistently associated with increased susceptibility to infection and its serious consequences. This has been attributed to the critical role of HDL in maintaining cellular lipid homeostasis, which is essential for the proper functioning of immune and structural cells. HDL, a multifunctional particle, exerts pleiotropic effects in host defense against pathogens. It functions as a natural nanoparticle, capable of sequestering and neutralizing potentially harmful substances like bacterial lipopolysaccharides. HDL possesses antiviral activity, preventing viruses from entering or fusing with host cells, thereby halting their replication cycle. Understanding the complex relationship between HDL and the immune system may reveal innovative targets for developing new treatments to combat infectious diseases and improve patient outcomes. This review aims to emphasize the role of HDL in influencing the course of bacterial and viral infections and its and its therapeutic potential.
摘要：
低水平的高密度脂蛋白（HDL）和受损的HDL功能一直与感染易感性增加及其严重后果相关。这归因于HDL在维持细胞脂质稳态中的关键作用，这对于免疫细胞和结构细胞的正常运作至关重要。HDL,多功能粒子,在宿主防御病原体中发挥多效性作用。它作为一种天然纳米粒子，能够螯合和中和细菌脂多糖等潜在有害物质。HDL具有抗病毒活性，防止病毒进入宿主细胞或与宿主细胞融合，从而停止他们的复制周期。了解HDL与免疫系统之间的复杂关系可能会揭示开发新的治疗方法以对抗传染病并改善患者预后的创新目标。这篇综述旨在强调HDL在影响细菌和病毒感染过程中的作用及其治疗潜力。
