Abstract：
Neurological disorders are a diverse group of conditions that can significantly impact individuals\' quality of life. The maintenance of neural microenvironment homeostasis is essential for optimal physiological cellular processes. Perturbations in this delicate balance underlie various pathological manifestations observed across various neurological disorders. Current treatments for neurological disorders face substantial challenges, primarily due to the formidable blood-brain barrier and the intricate nature of neural tissue structures. These obstacles have resulted in a paucity of effective therapies and inefficiencies in patient care. Exosomes, nanoscale vesicles that contain a complex repertoire of biomolecules, are identifiable in various bodily fluids. They hold substantial promise in numerous therapeutic interventions due to their unique attributes, including targeted drug delivery mechanisms and the ability to cross the BBB, thereby enhancing their therapeutic potential. In this review, we investigate the therapeutic potential of exosomes across a range of neurological disorders, including neurodegenerative disorders, traumatic brain injury, peripheral nerve injury, brain tumors, and stroke. Through both in vitro and in vivo studies, our findings underscore the beneficial influence of exosomes in enhancing the neural microenvironment following neurological diseases, offering promise for improved neural recovery and management in these conditions.
摘要：
神经系统疾病是一组可显著影响个体生活质量的疾病。维持神经微环境稳态对于最佳生理细胞过程至关重要。这种微妙平衡的扰动是在各种神经系统疾病中观察到的各种病理表现的基础。目前神经系统疾病的治疗面临巨大挑战，主要是由于强大的血脑屏障和神经组织结构的复杂性质。这些障碍导致缺乏有效的疗法和患者护理的低效率。外泌体,含有复杂生物分子库的纳米级囊泡，可以在各种体液中识别。由于其独特的属性，它们在许多治疗干预中都有很大的希望，包括靶向药物递送机制和跨越BBB的能力，从而提高他们的治疗潜力。在这次审查中,我们研究了外泌体在一系列神经系统疾病中的治疗潜力，包括神经退行性疾病，创伤性脑损伤,周围神经损伤,脑肿瘤,和中风。通过体外和体内研究，我们的发现强调了外泌体在增强神经系统疾病后的神经微环境方面的有益影响，为改善这些条件下的神经恢复和管理提供了希望。
