Abstract：
OBJECTIVE: The purpose of the present study was to explore the latent growth trajectory of body mass index (BMI) from birth to 24 months and comprehensively analyze body composition development influencing factor in preschool children.
METHODS: This ambidirectional cohort study was conducted in Tianjin, China, from 2017 to 2020, and children\'s regular medical check-up data from birth to 24 months were retrospectively collected. The growth models were used to fit BMI z-score trajectories for children aged 0-24 months. Crossover analysis and interaction model were used to explore the interaction of influencing factors.
RESULTS: We analyzed the growth trajectories of 3217 children, of these, 1493 children with complete follow-up data were included in the influencing factors analysis. Trajectories and parental prepregnancy BMI (ppBMI) were independent factors influencing children\'s body composition. When paternal ppBMI ≥24 kg/m2, regardless of maternal ppBMI, the risk of overweight and obesity in senior-class children was increased. The high trajectories played a partial mediating role in the association between paternal ppBMI and body composition in preschool children.
CONCLUSIONS: BMI growth in children aged 0-24 months can be divided into three latent trajectories: low, middle, and high. These trajectories and parental ppBMI were independent and interactive factors influencing children\'s body composition. The high trajectories played a partial mediating role in the association between paternal ppBMI and body composition in preschool children. It is necessary to pay attention to the BMI growth level of children aged 0-24 months, which plays an important role in the development of body fat in the future.
METHODS: This ambidirectional cohort study was conducted in Tianjin, China, from 2017 to 2020, and children\'s regular medical check-up data from birth to 24 months were retrospectively collected. The growth models were used to fit BMI z-score trajectories for children aged 0-24 months. Crossover analysis and interaction model were used to explore the interaction of influencing factors.
RESULTS: We analyzed the growth trajectories of 3217 children, of these, 1493 children with complete follow-up data were included in the influencing factors analysis. Trajectories and parental prepregnancy BMI (ppBMI) were independent factors influencing children\'s body composition. When paternal ppBMI ≥24 kg/m2, regardless of maternal ppBMI, the risk of overweight and obesity in senior-class children was increased. The high trajectories played a partial mediating role in the association between paternal ppBMI and body composition in preschool children.
CONCLUSIONS: BMI growth in children aged 0-24 months can be divided into three latent trajectories: low, middle, and high. These trajectories and parental ppBMI were independent and interactive factors influencing children\'s body composition. The high trajectories played a partial mediating role in the association between paternal ppBMI and body composition in preschool children. It is necessary to pay attention to the BMI growth level of children aged 0-24 months, which plays an important role in the development of body fat in the future.
摘要：
目的：本研究旨在探讨学龄前儿童从出生到24个月体重指数(BMI)的潜在增长轨迹，并综合分析其身体成分发育影响因素。
方法：这项双向队列研究在天津进行，中国,从2017年到2020年,回顾性收集了儿童从出生到24个月的常规体检数据.生长模型用于拟合0-24个月儿童的BMIz评分轨迹。采用交叉分析和交互作用模型探讨影响因素的交互作用。
结果：我们分析了3217名儿童的成长轨迹，其中，1493名有完整随访数据的儿童纳入影响因素分析。运动轨迹和父母孕前BMI(ppBMI)是影响儿童体成分的独立因素。当父亲ppBMI≥24kg/m2时，无论母亲ppBMI如何，高年级儿童超重和肥胖的风险增加.在学龄前儿童中，高轨迹在父系ppBMI与身体成分之间的关联中起部分中介作用。
结论：0-24个月儿童的BMI增长可分为三个潜在轨迹：低，中间,和高。这些轨迹和父母ppBMI是影响儿童身体成分的独立和互动因素。在学龄前儿童中，高轨迹在父系ppBMI与身体成分之间的关联中起部分中介作用。有必要关注0-24个月儿童的BMI增长水平，这在未来身体脂肪的发展中起着重要作用。
方法：这项双向队列研究在天津进行，中国,从2017年到2020年,回顾性收集了儿童从出生到24个月的常规体检数据.生长模型用于拟合0-24个月儿童的BMIz评分轨迹。采用交叉分析和交互作用模型探讨影响因素的交互作用。
结果：我们分析了3217名儿童的成长轨迹，其中，1493名有完整随访数据的儿童纳入影响因素分析。运动轨迹和父母孕前BMI(ppBMI)是影响儿童体成分的独立因素。当父亲ppBMI≥24kg/m2时，无论母亲ppBMI如何，高年级儿童超重和肥胖的风险增加.在学龄前儿童中，高轨迹在父系ppBMI与身体成分之间的关联中起部分中介作用。
结论：0-24个月儿童的BMI增长可分为三个潜在轨迹：低，中间,和高。这些轨迹和父母ppBMI是影响儿童身体成分的独立和互动因素。在学龄前儿童中，高轨迹在父系ppBMI与身体成分之间的关联中起部分中介作用。有必要关注0-24个月儿童的BMI增长水平，这在未来身体脂肪的发展中起着重要作用。
