Abstract：
OBJECTIVE: Optimism and purpose in life are associated with improved health outcomes. More information is needed on biological mechanisms, including immunosenescence. We investigated if psychological well-being is associated with healthier immunosenescence-related measures including naïve and terminally differentiated CD4+ and CD8+ T cell percentages, CD4+:CD8+, and cytomegalovirus (CMV) IgG response.
METHODS: Participants were adults over age 50 from the Health and Retirement Study. Optimism was measured using the Life Orientation Test Revised. Purpose in life was assessed using the subscale from the Ryff psychological well-being measure. We examined the cross-sectional associations of optimism and purpose in life with measures of T cell subsets using linear regression and with CMV IgG using ordered logit regression, controlling for potential confounding factors.
RESULTS: The final analytic sample ranged from 7250 to 7870. After adjusting for sociodemographic factors, a 1-SD increment in optimism was associated with the percentage of naïve CD4+ T cells increasing by 0.6 (95%CI 0.2%, 1.0%). A 1-SD increment in purpose in life was associated with the percentage of naïve CD4+ T cells increasing by 0.9 (95%CI 0.5%, 1.3%) after adjusting for sociodemographic factors and the association was maintained after further adjustments for health conditions, depression, and health behaviors. For naïve CD8+ T cell percentages, CD4:CD8 ratios, and CMV IgG antibodies, associations were seen only in models that adjusted for age. No significant associations were seen in any models for the terminally differentiated CD4+ and CD8+ T cells.
CONCLUSIONS: We found associations of optimism and purpose in life with naïve CD4+ T cell percentages.
METHODS: Participants were adults over age 50 from the Health and Retirement Study. Optimism was measured using the Life Orientation Test Revised. Purpose in life was assessed using the subscale from the Ryff psychological well-being measure. We examined the cross-sectional associations of optimism and purpose in life with measures of T cell subsets using linear regression and with CMV IgG using ordered logit regression, controlling for potential confounding factors.
RESULTS: The final analytic sample ranged from 7250 to 7870. After adjusting for sociodemographic factors, a 1-SD increment in optimism was associated with the percentage of naïve CD4+ T cells increasing by 0.6 (95%CI 0.2%, 1.0%). A 1-SD increment in purpose in life was associated with the percentage of naïve CD4+ T cells increasing by 0.9 (95%CI 0.5%, 1.3%) after adjusting for sociodemographic factors and the association was maintained after further adjustments for health conditions, depression, and health behaviors. For naïve CD8+ T cell percentages, CD4:CD8 ratios, and CMV IgG antibodies, associations were seen only in models that adjusted for age. No significant associations were seen in any models for the terminally differentiated CD4+ and CD8+ T cells.
CONCLUSIONS: We found associations of optimism and purpose in life with naïve CD4+ T cell percentages.
摘要：
目标：生活中的乐观和目标与健康结果的改善有关。需要更多关于生物学机制的信息，包括免疫衰老。我们调查了心理健康是否与更健康的免疫衰老相关指标相关，包括初始和终末分化的CD4+和CD8+T细胞百分比，CD4+：CD8+，和巨细胞病毒（CMV）IgG反应。
方法：参与者是健康与退休研究中50岁以上的成年人。使用修订的生活取向测试测量乐观度。使用Ryff心理健康测量的子量表评估生活目的。我们使用线性回归分析T细胞亚群和使用有序logit回归分析CMVIgG，研究了乐观情绪和生活目标的横断面关联。控制潜在的混杂因素。
结果：最终的分析样本范围为7250至7870。在调整了社会人口因素后，乐观的1-SD增量与初始CD4+T细胞的百分比增加0.6相关(95CI0.2%，1.0%）。生活目的的1-SD增加与初始CD4+T细胞的百分比增加0.9相关（95CI0.5%，1.3%）在调整了社会人口统计学因素后，在进一步调整了健康状况后，该协会得以维持，抑郁症,和健康行为。对于幼稚CD8+T细胞百分比，CD4：CD8比率，和CMVIgG抗体，仅在调整了年龄的模型中发现了关联.对于终末分化的CD4+和CD8+T细胞,在任何模型中均未观察到显著的关联。
结论：我们发现乐观和生活目标与初始CD4+T细胞百分比有关。
方法：参与者是健康与退休研究中50岁以上的成年人。使用修订的生活取向测试测量乐观度。使用Ryff心理健康测量的子量表评估生活目的。我们使用线性回归分析T细胞亚群和使用有序logit回归分析CMVIgG，研究了乐观情绪和生活目标的横断面关联。控制潜在的混杂因素。
结果：最终的分析样本范围为7250至7870。在调整了社会人口因素后，乐观的1-SD增量与初始CD4+T细胞的百分比增加0.6相关(95CI0.2%，1.0%）。生活目的的1-SD增加与初始CD4+T细胞的百分比增加0.9相关（95CI0.5%，1.3%）在调整了社会人口统计学因素后，在进一步调整了健康状况后，该协会得以维持，抑郁症,和健康行为。对于幼稚CD8+T细胞百分比，CD4：CD8比率，和CMVIgG抗体，仅在调整了年龄的模型中发现了关联.对于终末分化的CD4+和CD8+T细胞,在任何模型中均未观察到显著的关联。
结论：我们发现乐观和生活目标与初始CD4+T细胞百分比有关。
