METHODS: A cross-sectional survey was conducted with a sample of 824 patients with BC undergoing chemotherapy. The cancer fatigue scale was administered to assess CRF. Hematological indicators, including neutrophils, lymphocytes, monocytes, and platelets, were retrieved from routine blood test. Network analyses were used to examine the associations among them.
RESULTS: Among 824 participants, the mean score of CRF was (27 ± 10), ranging from 0 to 57. The results of network models indicated that physical fatigue was negatively linked to lymphocyte counts (weight = - 0.161), and affective fatigue was positively associated with neutrophil counts (weight = 0.070). Additionally, physical fatigue was positively linked to the platelet-to-lymphocyte ratio (PLR) (weight = 0.049).
CONCLUSIONS: There were preliminary associations of counts of three WBC types, platelet counts, and systemic inflammatory indices, with distinct dimensions of CRF in patients with BC. Findings provide empirical support for the cellular basis of fatigue-associated inflammatory states.
方法:对824例接受化疗的BC患者进行横断面调查。给予癌症疲劳量表以评估CRF。血液学指标,包括中性粒细胞,淋巴细胞,单核细胞,和血小板,是从常规血液检查中取回的。使用网络分析来检查它们之间的关联。
结果:在824名参与者中,CRF的平均得分为(27±10),从0到57。网络模型的结果表明,身体疲劳与淋巴细胞计数呈负相关(体重=-0.161),情感疲劳与中性粒细胞计数呈正相关(体重=0.070)。此外,身体疲劳与血小板/淋巴细胞比率(PLR)呈正相关(体重=0.049).
结论:三种白细胞计数有初步关联,血小板计数,全身炎症指标,BC患者CRF的不同维度。研究结果为疲劳相关炎症状态的细胞基础提供了经验支持。