Abstract：
Surgical operations are the preferred treatment for gastric perforation (GP) but incur postoperative complications such as gastrointestinal adhesions and bacterial infections, leading to inefficient wound healing and serious complications that may even threaten the life of the patient. Developing hydrogel dressings capable of adapting to the gastric environment (acid) and decreasing visceral adhesions and bacterial infections after GP treatment is crucial. In this article, we developed an injectable, self-healing hydrogel using cation-π interactions between protonated amines and aromatic rings under acidic conditions and explored it for GP repair. The hydrogels demonstrate exceptional self-healing capabilities under acidic conditions and can be effectively tailored for the gastric environment. In addition, the hydrogel demonstrated significant efficacy in preventing gastrointestinal adhesion, reducing inflammation, promoting angiogenesis, and effectively facilitating wound healing in a rat GP model. This novel hydrogel demonstrates adaptability to the gastric environment, rendering it highly promising for potential applications in gastric trauma healing.
摘要：
外科手术是胃穿孔（GP）的首选治疗方法，但会导致术后并发症，如胃肠道粘连和细菌感染，导致无效的伤口愈合和严重的并发症，甚至可能威胁到患者的生命。开发能够适应胃环境（酸）并减少GP治疗后内脏粘连和细菌感染的水凝胶敷料至关重要。在这篇文章中,我们开发了一种注射剂，在酸性条件下使用质子化胺与芳香环之间的阳离子-π相互作用进行自修复水凝胶，并探索其用于GP修复。水凝胶在酸性条件下表现出优异的自修复能力,并且可以针对胃环境有效地定制。此外,水凝胶在预防胃肠道粘连方面表现出显著功效，减少炎症，促进血管生成，并有效促进大鼠GP模型的伤口愈合。这种新型的水凝胶证明了对胃环境的适应性，使其在胃创伤愈合中的潜在应用非常有希望。
