Abstract：
Thyroxine, a key regulator of metabolic pathways, plays a pivotal role in glucose metabolism and the maintenance of glucose homeostasis. In clinical practice, L-thyroxine replacement therapy is commonly prescribed for patients with hypothyroidism. However, the specific effects of L-thyroxine and thyroidectomy (TX) on glucose levels remain an area of interest and investigation. In this study, 20 rats were divided into two groups (n=10 per group). The TX group (male and female rats) underwent thyroidectomy for 4 weeks. After 4 weeks, male and female thyroidectomized rats received L-thyroxine (10 μg/100 g/day, intraperitoneally) for 4 weeks. The rats\' weights were monitored weekly post-surgery. Compared to the initial level, thyroidectomy resulted in weight loss, whereas L-thyroxine replacement therapy normalized the weight loss induced by thyroidectomy. Additionally, thyroidectomy led to impaired glucose levels, which were restored to normal levels with L-thyroxine treatment. These findings underscore the impact of thyroid function on glucose metabolism and highlight the potential therapeutic role of L-thyroxine.
摘要：
甲状腺素,代谢途径的关键调节剂，在葡萄糖代谢和维持葡萄糖稳态中起着关键作用。在临床实践中,甲状腺功能减退症患者通常使用L-甲状腺素替代疗法。然而,左旋甲状腺素和甲状腺切除术(TX)对血糖水平的具体影响仍是一个值得关注和研究的领域.在这项研究中,将20只大鼠分为两组(每组n=10)。TX组(雄性和雌性大鼠)行甲状腺切除术4周。4周后,雄性和雌性甲状腺切除术大鼠接受L-甲状腺素（10μg/100g/天，腹膜内）4周。术后每周监测大鼠体重。与初始水平相比，甲状腺切除术导致体重减轻，而L-甲状腺素替代治疗使甲状腺切除术引起的体重减轻正常化.此外,甲状腺切除术导致葡萄糖水平受损，L-甲状腺素治疗后恢复到正常水平。这些发现强调了甲状腺功能对葡萄糖代谢的影响，并强调了L-甲状腺素的潜在治疗作用。
