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Abstract：
While liver fibrosis remains a serious, progressive, chronic liver disease, and factors causing damage persist, liver fibrosis may develop into cirrhosis and liver cancer. However, short-term liver fibrosis is reversible. Therefore, an early diagnosis of liver fibrosis in the reversible transition phase is important for effective treatment of liver diseases. Chitinase-3-like protein 1 (CHI3L1), an inflammatory response factor that participates in various biological processes and is abundant in liver tissue, holds promise as a potential biomarker for liver diseases. Here, we aimed to review research developments regarding serum CHI3L1 in relation to the pathophysiology and diagnosis of liver fibrosis of various etiologies, providing a reference for the diagnosis, treatment, and prognosis of liver diseases.
摘要：
虽然肝纤维化仍然严重，进步,慢性肝病,造成损害的因素仍然存在，肝纤维化可能发展为肝硬化和肝癌。然而,短期肝纤维化是可逆的。因此,在可逆过渡阶段肝纤维化的早期诊断对于有效治疗肝病很重要。几丁质酶-3-样蛋白1(CHI3L1),一种参与各种生物过程的炎症反应因子，在肝脏组织中含量丰富，有望成为肝脏疾病的潜在生物标志物。这里,我们旨在回顾血清CHI3L1与各种病因肝纤维化的病理生理学和诊断相关的研究进展，为诊断提供参考，治疗,和肝脏疾病的预后。
