PDF(Pubmed)
Abstract：
Plateletpheresis has become a pivotal part of transfusion medicine. With the increasing demand for plateletpheresis, donor safety is an area of concern because plateletpheresis alters donor hematological parameters. For a better understanding of plateletpheresis, a systemic review is needed to study more evidence-based aspects of plateletpheresis. Electronic databases PubMed, Google Scholar, and Cochrane Library were used to find articles from January 1, 1980, to May 23, 2024. The random effect model was used to meta-analyze the effect of plateletpheresis on hematocrit, hemoglobin, and red blood cell (RBC) count. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was followed. A total of 24 studies were found; the effect of plateletpheresis on hemoglobin, hematocrit, and RBC count was studied in the following respective numbers of donors: 3,374, 3,374, and 690. A decrease of hemoglobin, hematocrit, and RBC count was observed after plateletpheresis having a weighted mean difference (WMD) of 0.50 (95%CI = -0.72 to -0.27), WMD of -1.36 (95%CI = -2.05 to -0.66), and WMD of -0.18 (95%CI = -0.23 to -0.12), respectively. Plateletpheresis shows a decrease in the value of hematological parameters such as hemoglobin, hematocrit, and erythrocyte count due to blood loss in the kits employed in the procedure; cell lysis was also seen because of exposure of erythrocytes to stress or change in osmotic pressure. Thus, strict criteria for donation must be developed for better safety of the donors. Improved automated cell separators for plateletpheresis should be made available in blood banks to ensure good quality hematologic products. Our findings suggest that the duration of the procedure should be decreased.
摘要：
血小板置换术已成为输血医学的关键部分。随着血小板置换的需求不断增加,供体安全性是一个值得关注的领域，因为血小板置换会改变供体血液学参数。为了更好地理解血小板分离，需要进行系统评价,以研究更多基于证据的血小板分离方面.电子数据库PubMed,谷歌学者，和Cochrane图书馆用于查找1980年1月1日至2024年5月23日的文章。随机效应模型用于荟萃分析血小板置换对红细胞压积的影响，血红蛋白,和红细胞（RBC）计数。遵循系统审查和荟萃分析（PRISMA）指南的首选报告项目。共发现24项研究；血小板分离对血红蛋白的影响，血细胞比容,在以下相应数量的供体中研究RBC计数:3,374、3,374和690。血红蛋白减少,血细胞比容,血小板分离后观察到红细胞计数，加权平均差（WMD）为0.50（95CI=-0.72至-0.27），大规模毁灭性武器为-1.36（95CI=-2.05至-0.66），WMD为-0.18（95CI=-0.23至-0.12），分别。血小板分离显示血液参数如血红蛋白的值降低，血细胞比容,和由于该程序中使用的试剂盒中的失血而导致的红细胞计数；由于红细胞暴露于压力或渗透压变化，还可以看到细胞裂解。因此，必须制定严格的捐赠标准，以提高捐赠者的安全性。血库中应提供用于血小板分离的改进的自动细胞分离器，以确保优质的血液学产品。我们的研究结果表明，应缩短手术时间。
