Abstract：
UNASSIGNED: Dry powder inhaler (DPI) formulations are gaining attention as universal formulations with applications in a diverse range of drug formulations. The practical application of DPIs to pulmonary drugs requires enhancing their delivery efficiency to the target sites for various treatment modalities. Previous reviews have not explored the relation between particle morphology and delivery to different pulmonary regions. This review introduces new approaches to improve targeted DPI delivery using novel particle design such as supraparticles and metal-organic frameworks based on cyclodextrin.
UNASSIGNED: This review focuses on the design of DPI formulations using polysaccharides, promising excipients not yet approved by regulatory agencies. These excipients can be used to design various particle morphologies by controlling their physicochemical properties and manufacturing methods.
UNASSIGNED: Challenges associated with DPI formulations include poor access to the lungs and low delivery efficiency to target sites in the lung. The restricted applicability of typical excipients contributes to their limited use. However, new formulations based on polysaccharides are expected to establish a technological foundation for the development of DPIs capable of delivering modalities specific to different lung target sites, thereby enhancing drug delivery.
UNASSIGNED: This review focuses on the design of DPI formulations using polysaccharides, promising excipients not yet approved by regulatory agencies. These excipients can be used to design various particle morphologies by controlling their physicochemical properties and manufacturing methods.
UNASSIGNED: Challenges associated with DPI formulations include poor access to the lungs and low delivery efficiency to target sites in the lung. The restricted applicability of typical excipients contributes to their limited use. However, new formulations based on polysaccharides are expected to establish a technological foundation for the development of DPIs capable of delivering modalities specific to different lung target sites, thereby enhancing drug delivery.
摘要：
干粉吸入器(DPI)制剂作为在各种药物制剂中应用的通用制剂而受到关注。DPI对肺部药物的实际应用需要增强它们对各种治疗方式的目标部位的递送效率。以前的评论尚未探讨颗粒形态与递送到不同肺部区域之间的关系。这篇综述介绍了使用新型颗粒设计（例如超颗粒和基于环糊精的金属有机框架）改善靶向DPI递送的新方法。
■这篇综述的重点是使用多糖的DPI配方的设计，尚未获得监管机构批准的有前途的赋形剂。这些赋形剂可用于通过控制其物理化学性质和制造方法来设计各种颗粒形态。
与DPI制剂相关的挑战包括对肺的接近性差和对肺中的靶部位的递送效率低。典型赋形剂的受限适用性导致其有限的使用。然而,基于多糖的新制剂有望为DPI的开发奠定技术基础，该DPI能够提供针对不同肺靶位点的特异性方式。从而增强药物递送。
■这篇综述的重点是使用多糖的DPI配方的设计，尚未获得监管机构批准的有前途的赋形剂。这些赋形剂可用于通过控制其物理化学性质和制造方法来设计各种颗粒形态。
与DPI制剂相关的挑战包括对肺的接近性差和对肺中的靶部位的递送效率低。典型赋形剂的受限适用性导致其有限的使用。然而,基于多糖的新制剂有望为DPI的开发奠定技术基础，该DPI能够提供针对不同肺靶位点的特异性方式。从而增强药物递送。
