PDF(Pubmed)
Abstract：
OBJECTIVE: Rett syndrome (RTT) is characterized by neurological regression. This pioneering study investigated the effect of age on brain volume reduction by analyzing magnetic resonance imaging findings in participants with RTT, ranging from toddlers to adults.
METHODS: Functional evaluation and neuroimaging were performed. All scans were acquired using a Siemens Tim Trio 3 T scanner with a 32-channel head coil.
RESULTS: The total intracranial volume and cerebral white matter volume significantly increased with age in the control group compared with that in the RTT group (p < 0.05). Cortical gray matter volume reduction in the RTT group continued to increase in bilateral parietal lobes and left occipital lobes (p < 0.05). The differences in cortical gray matter volume between typically developing brain and RTT-affected brain may tend to continuously increase until adulthood in both temporal lobes although not significant after correction for multiple comparison.
CONCLUSIONS: A significant reduction in brain volume was observed in the RTT group. Cortical gray matter volume in the RTT group continued to reduce in bilateral parietal lobes and left occipital lobes. These results provide a baseline for future studies on the effect of RTT treatment and related neuroscience research.
METHODS: Functional evaluation and neuroimaging were performed. All scans were acquired using a Siemens Tim Trio 3 T scanner with a 32-channel head coil.
RESULTS: The total intracranial volume and cerebral white matter volume significantly increased with age in the control group compared with that in the RTT group (p < 0.05). Cortical gray matter volume reduction in the RTT group continued to increase in bilateral parietal lobes and left occipital lobes (p < 0.05). The differences in cortical gray matter volume between typically developing brain and RTT-affected brain may tend to continuously increase until adulthood in both temporal lobes although not significant after correction for multiple comparison.
CONCLUSIONS: A significant reduction in brain volume was observed in the RTT group. Cortical gray matter volume in the RTT group continued to reduce in bilateral parietal lobes and left occipital lobes. These results provide a baseline for future studies on the effect of RTT treatment and related neuroscience research.
摘要：
目的：Rett综合征（RTT）的特征是神经系统退化。这项开创性研究通过分析RTT参与者的磁共振成像发现，调查了年龄对大脑体积减少的影响。从幼儿到成人。
方法：进行功能评估和神经影像学检查。使用具有32通道头部线圈的SiemensTimTrio3T扫描仪获得所有扫描。
结果：与RTT组相比，对照组的颅内总体积和脑白质体积随年龄的增长显着增加（p<0.05）。RTT组皮质灰质体积减少，双侧顶叶和左枕叶继续增加（p<0.05）。通常发育中的大脑和受RTT影响的大脑之间的皮质灰质体积的差异可能倾向于在两个颞叶中持续增加直到成年，尽管在多次比较校正后并不显着。
结论：在RTT组中观察到脑容量显著减少。RTT组双侧顶叶和左枕叶皮质灰质体积持续减少。这些结果为未来研究RTT治疗效果和相关神经科学研究提供了基线。
方法：进行功能评估和神经影像学检查。使用具有32通道头部线圈的SiemensTimTrio3T扫描仪获得所有扫描。
结果：与RTT组相比，对照组的颅内总体积和脑白质体积随年龄的增长显着增加（p<0.05）。RTT组皮质灰质体积减少，双侧顶叶和左枕叶继续增加（p<0.05）。通常发育中的大脑和受RTT影响的大脑之间的皮质灰质体积的差异可能倾向于在两个颞叶中持续增加直到成年，尽管在多次比较校正后并不显着。
结论：在RTT组中观察到脑容量显著减少。RTT组双侧顶叶和左枕叶皮质灰质体积持续减少。这些结果为未来研究RTT治疗效果和相关神经科学研究提供了基线。
