Abstract：
The number of midlife women transitioning into menopause is substantial, with more than 1 million women in the United States entering menopause each year. Vasomotor symptoms (VMS), mood and sleep disturbances, and sexual problems are common during the menopause transition yet often go untreated. Menopausal hormone therapy is the most effective treatment of VMS, and the benefits typically outweigh the risks for women without contraindications who are younger than 60 years or within 10 years from menopause onset. For women who cannot or choose not to use hormone therapy, nonhormone prescription options exist to treat VMS. Many of these therapies have secondary benefits beyond VMS relief. For example, whereas paroxetine is Food and Drug Administration approved to treat VMS, it can also help with depressive and anxiety symptoms. The aim of this paper is to summarize prescription treatments of VMS and their secondary benefits for other common symptoms experienced by midlife women. The tools presented will help clinicians caring for midlife women provide individualized, comprehensive care with the goal of improving their quality of life during the menopause transition and beyond.
摘要：
过渡到更年期的中年女性人数很多，美国每年有100多万女性进入更年期。血管舒缩症状（VMS），情绪和睡眠障碍，在更年期过渡期间，性问题很常见，但经常得不到治疗。更年期激素治疗是VMS最有效的治疗方法,对于60岁以下或绝经后10年内没有禁忌症的女性，其益处通常大于风险。对于不能或选择不使用激素治疗的女性，存在治疗VMS的非激素处方选择。这些疗法中的许多具有超出VMS缓解的次要益处。例如,帕罗西汀被食品和药物管理局批准用于治疗VMS，它还可以帮助抑郁和焦虑症状。本文的目的是总结VMS的处方治疗及其对中年女性其他常见症状的次要益处。提供的工具将帮助临床医生照顾中年女性提供个性化，全面的护理，目的是在更年期过渡期及以后提高他们的生活质量。
