75 consecutive SSc patients were enrolled and serum TSLP levels were measured. The presence of history of DUs (HDU) was evaluated. Recurrent new DUs were defined as the presence of at least 3 episodes of DUs in a 12-months follow up period. The risk of developing new DUs was calculated by applying the capillaroscopic skin ulcer risk index (CSURI).
The median value of TSLP was higher in patients with HDU than patients without HDU [181.67 pg/ml (IQR 144.67; 265.66) vs 154.67 pg/ml (IQR 110.67; 171.33), p < 0.01]. The median value of TSLP was higher in patients with an increased CSURI index than patients without an increased CSURI [188 pg/ml (IQR 171.33; 246.33) vs 159.33 pg/ml (IQR 128.67; 218), p < 0.01]. Kaplan-Meier curves demonstrated that free survival from new DUs was significantly (p < 0.01) lower in SSc patients with increased TSLP serum levels.
TSLP might have a key role in digital microvascular damage of SSc patients.
方法:纳入75例连续SSc患者,测定血清TSLP水平。评估了DU(HDU)历史的存在。反复出现的新DU被定义为在12个月的随访期内出现至少3次DU。通过应用毛细管镜皮肤溃疡风险指数(CSURI)计算开发新DU的风险。
结果:HDU患者的TSLP中位值高于无HDU患者[181.67pg/ml(IQR144.67;265.66)vs154.67pg/ml(IQR110.67;171.33),p<0.01]。CSURI指数升高的患者的TSLP中位值高于CSURI指数升高的患者[188pg/ml(IQR171.33;246.33)vs159.33pg/ml(IQR128.67;218),p<0.01]。Kaplan-Meier曲线表明,在TSLP血清水平升高的SSc患者中,新DU的自由生存率显着降低(p<0.01)。
结论:TSLP可能在SSc患者的数字微血管损伤中起关键作用。