组蛋白 3 上赖氨酸 27 的单甲基化赋予终生对压力的易感性。
关键词: H3K27me1 SUZ12 depression early life stress histone modifications medium spiny neurons nucleus accumbens polycomb repressive complex 2
Mesh : Animals Histones / metabolism Stress, Psychological / metabolism genetics Mice Nucleus Accumbens / metabolism Methylation Lysine / metabolism Polycomb Repressive Complex 2 / metabolism genetics Male Mice, Inbred C57BL Neurons / metabolism Protein Processing, Post-Translational Social Defeat
来 源:
DOI:10.1016/j.neuron.2024.06.006
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