PDF(Pubmed)
Abstract：
BACKGROUND: The pleomorphic variant is the least common and consequently, the least known subtype of liposarcomas. It represents <5 % of all liposarcomas and develops during late adulthood.
METHODS: We report the case of a 77-year-old male who presented with pain in the right iliac fossa and right inguinal region. A CT scan revealed a stony lesion at the level of the cecum. A right hemicolectomy was performed, and the pathology report was positive for pleomorphic liposarcoma. Consequently, he was referred for adjuvant radiotherapy.
UNASSIGNED: Molecular analysis has validated the distinction of liposarcoma subtypes, although histological subtype remains the reliable prognostic parameter in daily practice, recent evidence suggests that genetic profiles may eventually influence risk stratification of individual patients.
CONCLUSIONS: The pleomorphic subtype of liposarcomas is infrequent, and they are very rare in the cecum, so it is currently recommended that patients be evaluated by a multidisciplinary team to make a therapeutic decision as it is a subtype of very aggressive behavior, before initiating any type of oncologic treatment.
METHODS: We report the case of a 77-year-old male who presented with pain in the right iliac fossa and right inguinal region. A CT scan revealed a stony lesion at the level of the cecum. A right hemicolectomy was performed, and the pathology report was positive for pleomorphic liposarcoma. Consequently, he was referred for adjuvant radiotherapy.
UNASSIGNED: Molecular analysis has validated the distinction of liposarcoma subtypes, although histological subtype remains the reliable prognostic parameter in daily practice, recent evidence suggests that genetic profiles may eventually influence risk stratification of individual patients.
CONCLUSIONS: The pleomorphic subtype of liposarcomas is infrequent, and they are very rare in the cecum, so it is currently recommended that patients be evaluated by a multidisciplinary team to make a therapeutic decision as it is a subtype of very aggressive behavior, before initiating any type of oncologic treatment.
摘要：
背景：多态变体是最不常见的，因此，最不为人所知的脂肪肉瘤亚型。它占所有脂肪肉瘤的<5％，并在成年后期发展。
方法：我们报告了一例77岁男性患者，患者右侧髂窝和右侧腹股沟区疼痛。CT扫描显示盲肠水平有石质病变。进行了右半结肠切除术,病理报告为多形性脂肪肉瘤阳性。因此,他被转介接受辅助放疗。
■分子分析验证了脂肪肉瘤亚型的区别，尽管组织学亚型仍然是日常实践中可靠的预后参数，最近的证据表明，基因谱最终可能会影响个体患者的风险分层。
结论：脂肪肉瘤的多形性亚型很少见，它们在盲肠中非常罕见，因此，目前建议由多学科团队对患者进行评估以做出治疗决定，因为这是一种非常攻击性行为的亚型，在开始任何类型的肿瘤治疗之前。
方法：我们报告了一例77岁男性患者，患者右侧髂窝和右侧腹股沟区疼痛。CT扫描显示盲肠水平有石质病变。进行了右半结肠切除术,病理报告为多形性脂肪肉瘤阳性。因此,他被转介接受辅助放疗。
■分子分析验证了脂肪肉瘤亚型的区别，尽管组织学亚型仍然是日常实践中可靠的预后参数，最近的证据表明，基因谱最终可能会影响个体患者的风险分层。
结论：脂肪肉瘤的多形性亚型很少见，它们在盲肠中非常罕见，因此，目前建议由多学科团队对患者进行评估以做出治疗决定，因为这是一种非常攻击性行为的亚型，在开始任何类型的肿瘤治疗之前。
