Abstract：
BACKGROUND: Burns are classified according to their mechanism of injury, depth, affected body area, affected region or part of the body, and extent of the lesions. Topical insulin modulates the healing process. However, studies evaluating the effects of topical insulin treatment on burns in human patients are lacking.
OBJECTIVE: The purpose of this study was to investigate the effects of topical insulin on healing time of second-degree burns.
METHODS: In this nonrandomized clinical trial, patients with second-degree burns were allocated to a control group (CG) or an intervention group (IG) in which wounds were treated with 1% silver sulfadiazine and topical insulin, respectively.
RESULTS: Healing time was significantly shorter in the IG relative to the CG (9.1 ± 1.9 days and 12.7 ± 3.3 days, respectively; P < .05). The estimated burn area was similar in both groups (CG 1.44 ± 1.0%; IG 1.42 ± 0.53%).
CONCLUSIONS: In this study, topical insulin reduced healing time in second-degree burns. Further investigation is warranted to support wider use in clinical practice.
OBJECTIVE: The purpose of this study was to investigate the effects of topical insulin on healing time of second-degree burns.
METHODS: In this nonrandomized clinical trial, patients with second-degree burns were allocated to a control group (CG) or an intervention group (IG) in which wounds were treated with 1% silver sulfadiazine and topical insulin, respectively.
RESULTS: Healing time was significantly shorter in the IG relative to the CG (9.1 ± 1.9 days and 12.7 ± 3.3 days, respectively; P < .05). The estimated burn area was similar in both groups (CG 1.44 ± 1.0%; IG 1.42 ± 0.53%).
CONCLUSIONS: In this study, topical insulin reduced healing time in second-degree burns. Further investigation is warranted to support wider use in clinical practice.
摘要：
背景：烧伤根据其损伤机制进行分类，深度,受影响的身体区域，受影响的区域或身体的一部分，和病变的程度。局部胰岛素调节愈合过程。然而,缺乏评估局部胰岛素治疗对人类患者烧伤影响的研究。
目的：本研究的目的是探讨局部胰岛素对二度烧伤愈合时间的影响。
方法：在这项非随机临床试验中，二度烧伤患者被分为对照组（CG）或干预组（IG），其中伤口接受1%磺胺嘧啶银和局部胰岛素治疗，分别。
结果：相对于CG，IG的愈合时间显着缩短（9.1±1.9天和12.7±3.3天，分别；P<0.05）。两组的估计烧伤面积相似（CG1.44±1.0％；IG1.42±0.53％）。
结论：在这项研究中，局部胰岛素减少二度烧伤的愈合时间。有必要进行进一步的研究，以支持在临床实践中的更广泛使用。
目的：本研究的目的是探讨局部胰岛素对二度烧伤愈合时间的影响。
方法：在这项非随机临床试验中，二度烧伤患者被分为对照组（CG）或干预组（IG），其中伤口接受1%磺胺嘧啶银和局部胰岛素治疗，分别。
结果：相对于CG，IG的愈合时间显着缩短（9.1±1.9天和12.7±3.3天，分别；P<0.05）。两组的估计烧伤面积相似（CG1.44±1.0％；IG1.42±0.53％）。
结论：在这项研究中，局部胰岛素减少二度烧伤的愈合时间。有必要进行进一步的研究，以支持在临床实践中的更广泛使用。
