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Abstract：
BACKGROUND: The present study reviewed the clinicopathological features and outcomes of bilateral lacrimal gland lesions.
METHODS: The data of 113 patients who underwent lacrimal gland biopsy at the West China Hospital of Sichuan University, China, between January 1, 2010, and December 31, 2021, are presented in this case series. The patients all presented with bilateral lacrimal gland lesions. The collected data included patient demographics, clinical features, the results of laboratory examinations, imaging presentations, histopathological diagnoses, treatments, and outcomes.
RESULTS: The mean age of the 113 enrolled patients was 47.4 ± 14.9 years (range, 11-77 years) with a predominance of females (54.9%, n = 62). The lacrimal gland was the source of the majority of biopsy tissue (98.2%, n = 111). The most prevalent etiology was immunoglobulin G4-related ophthalmic disease (IgG4-ROD) (32.7%, n = 37), followed by idiopathic orbital inflammation (IOI) (28.3%, n = 32), mucosa-associated lymphoid tissue (MALT) lymphoma (17.7%, n = 20), reactive lymphoid hyperplasia (RLH) (10.6%, n = 12), and mantle cell lymphoma (4.4%, n = 5). Patients with IOI were significantly younger than those with IgG4-ROD and MALT lymphoma (t = 2.932, P = 0.005; t = 3.865, P<0.001, respectively). Systemic symptoms were more prevalent among patients with IgG4-ROD (χ2 = 7.916, P = 0.005). The majority of patients were treated with surgery (53.1%, n = 60), with surgery combined with corticosteroid therapy (21.2%, n = 24) being the second most common treatment. The majority of patients (91.2%, n = 103) attained complete resolution, stable disease, or significant improvement.
CONCLUSIONS: In conclusion, there are several aetiologies associated with bilateral lacrimal gland lesions, the most prevalent being IgG4-ROD, IOI, and MALT lymphoma. Systemic symptoms were more common in patients with IgG4-ROD. The majority of patients who presented with bilateral lesions of the lacrimal glands responded satisfactorily to treatment, with favorable results.
METHODS: The data of 113 patients who underwent lacrimal gland biopsy at the West China Hospital of Sichuan University, China, between January 1, 2010, and December 31, 2021, are presented in this case series. The patients all presented with bilateral lacrimal gland lesions. The collected data included patient demographics, clinical features, the results of laboratory examinations, imaging presentations, histopathological diagnoses, treatments, and outcomes.
RESULTS: The mean age of the 113 enrolled patients was 47.4 ± 14.9 years (range, 11-77 years) with a predominance of females (54.9%, n = 62). The lacrimal gland was the source of the majority of biopsy tissue (98.2%, n = 111). The most prevalent etiology was immunoglobulin G4-related ophthalmic disease (IgG4-ROD) (32.7%, n = 37), followed by idiopathic orbital inflammation (IOI) (28.3%, n = 32), mucosa-associated lymphoid tissue (MALT) lymphoma (17.7%, n = 20), reactive lymphoid hyperplasia (RLH) (10.6%, n = 12), and mantle cell lymphoma (4.4%, n = 5). Patients with IOI were significantly younger than those with IgG4-ROD and MALT lymphoma (t = 2.932, P = 0.005; t = 3.865, P<0.001, respectively). Systemic symptoms were more prevalent among patients with IgG4-ROD (χ2 = 7.916, P = 0.005). The majority of patients were treated with surgery (53.1%, n = 60), with surgery combined with corticosteroid therapy (21.2%, n = 24) being the second most common treatment. The majority of patients (91.2%, n = 103) attained complete resolution, stable disease, or significant improvement.
CONCLUSIONS: In conclusion, there are several aetiologies associated with bilateral lacrimal gland lesions, the most prevalent being IgG4-ROD, IOI, and MALT lymphoma. Systemic symptoms were more common in patients with IgG4-ROD. The majority of patients who presented with bilateral lesions of the lacrimal glands responded satisfactorily to treatment, with favorable results.
摘要：
背景：本研究综述了双侧泪腺病变的临床病理特征和转归。
方法：收集四川大学华西医院113例泪腺活检患者的资料,中国,在2010年1月1日至2021年12月31日之间，将在本案例系列中介绍。患者均表现为双侧泪腺病变。收集的数据包括患者的人口统计，临床特征,实验室检查的结果，成像演示,组织病理学诊断,治疗,和结果。
结果：113名患者的平均年龄为47.4±14.9岁（范围，11-77岁)，女性占主导地位(54.9%，n=62）。泪腺是大多数活检组织的来源(98.2%,n=111）。最常见的病因是免疫球蛋白G4相关眼科疾病（IgG4-ROD）（32.7%，n=37),其次是特发性眼眶炎症（IOI）（28.3%，n=32),粘膜相关淋巴组织（MALT）淋巴瘤（17.7％，n=20),反应性淋巴样增生（RLH）（10.6%，n=12),和套细胞淋巴瘤（4.4%，n=5)。IOI患者明显小于IgG4-ROD和MALT淋巴瘤患者(t=2.932,P=0.005;t=3.865,P<0.001)。全身症状在IgG4-ROD患者中更为普遍(χ2=7.916,P=0.005)。大多数患者接受了手术治疗（53.1％，n=60),手术联合糖皮质激素治疗（21.2%，n=24）是第二常见的治疗方法。大多数患者（91.2%，n=103)达到完全分辨率，疾病稳定,或显著改善。
结论：结论：有几种病因与双侧泪腺病变有关，最普遍的是IgG4-ROD，IOI,和MALT淋巴瘤。全身症状在IgG4-ROD患者中更为常见。大多数表现为双侧泪腺病变的患者对治疗的反应令人满意，有良好的结果。
方法：收集四川大学华西医院113例泪腺活检患者的资料,中国,在2010年1月1日至2021年12月31日之间，将在本案例系列中介绍。患者均表现为双侧泪腺病变。收集的数据包括患者的人口统计，临床特征,实验室检查的结果，成像演示,组织病理学诊断,治疗,和结果。
结果：113名患者的平均年龄为47.4±14.9岁（范围，11-77岁)，女性占主导地位(54.9%，n=62）。泪腺是大多数活检组织的来源(98.2%,n=111）。最常见的病因是免疫球蛋白G4相关眼科疾病（IgG4-ROD）（32.7%，n=37),其次是特发性眼眶炎症（IOI）（28.3%，n=32),粘膜相关淋巴组织（MALT）淋巴瘤（17.7％，n=20),反应性淋巴样增生（RLH）（10.6%，n=12),和套细胞淋巴瘤（4.4%，n=5)。IOI患者明显小于IgG4-ROD和MALT淋巴瘤患者(t=2.932,P=0.005;t=3.865,P<0.001)。全身症状在IgG4-ROD患者中更为普遍(χ2=7.916,P=0.005)。大多数患者接受了手术治疗（53.1％，n=60),手术联合糖皮质激素治疗（21.2%，n=24）是第二常见的治疗方法。大多数患者（91.2%，n=103)达到完全分辨率，疾病稳定,或显著改善。
结论：结论：有几种病因与双侧泪腺病变有关，最普遍的是IgG4-ROD，IOI,和MALT淋巴瘤。全身症状在IgG4-ROD患者中更为常见。大多数表现为双侧泪腺病变的患者对治疗的反应令人满意，有良好的结果。
