Abstract：
Allicin (AL) is one of garlic-derived organosulfides and has a variety of pharmacological effects. Studies have reported that AL has notable inhibitory effects on liver cancer, gastric cancer, breast cancer, and other cancers. However, there are no relevant reports about its role in human nasopharyngeal carcinoma. Ferroptosis is an iron-dependent form of non-apoptotic regulated cell death. Increasing evidence indicates that induction of ferroptosis can inhibit the proliferation, migration, invasion, and survival of various cancer cells, which act as a tumor suppressor in cancer. In this study, we confirmed that AL can inhibit cell proliferation, migration, invasion, and survival in human nasopharyngeal carcinoma cells. Our finding shows that AL can induce the ferroptosis axis by decreasing the level of GSH and GPX4 and promoting the induction of toxic LPO and ROS. AL-mediated cytotoxicity in human nasopharyngeal carcinoma cells is dependent on ferroptosis. Therefore, AL has good anti-cancer properties and is expected to be a potential drug for the treatment of nasopharyngeal carcinoma.
摘要：
大蒜素是大蒜衍生的有机硫化物之一,具有多种药理作用。有研究报道AL对肝癌有显著的抑制作用,胃癌,乳腺癌,和其他癌症。然而,关于其在人鼻咽癌中的作用尚无相关报道。铁凋亡是非凋亡调节的细胞死亡的铁依赖性形式。越来越多的证据表明，铁凋亡的诱导可以抑制增殖，迁移,入侵,和各种癌细胞的存活，在癌症中充当肿瘤抑制因子。在这项研究中,我们证实AL可以抑制细胞增殖，迁移,入侵,和人鼻咽癌细胞的存活。我们的发现表明，AL可以通过降低GSH和GPX4的水平并促进毒性LPO和ROS的诱导来诱导铁凋亡轴。人鼻咽癌细胞中AL介导的细胞毒性依赖于铁凋亡。因此,AL具有良好的抗癌特性，有望成为治疗鼻咽癌的潜在药物。
