PDF(Pubmed)
Abstract：
UNASSIGNED: The study objective was to evaluate the prescription pattern and use of anti-seizure medications (ASMs) in patients with a seizure disorder and to evaluate if a change in the ASM dose had a beneficial effect on seizure control, observed through Therapeutic Drug Monitoring [TDM] level of ASMs.
UNASSIGNED: Details of anti-seizure medications with their therapeutic levels in the blood of patients with seizure disorder were analysed.
UNASSIGNED: Hospital-based retrospective analysis of patient case records.
UNASSIGNED: Therapeutic Drug Monitoring OPD of a tertiary care public teaching hospital.
UNASSIGNED: Case records of 918 patients with seizure disorder from 2016-2021.
UNASSIGNED: Data of men (53%) and women (47%) aged between 18-75 years was assessed About 62% (566/918) of patients were on levetiracetam, the most frequently prescribed anti-seizure medication. Whenever the ASMs dose was increased or decreased based on TDM levels, it was associated with a significant increase in the frequency of break-through seizures [OR- 5 (95% CI: 1.28-19.46)]. However, significant seizure control was observed when the patients were on the same maintenance dose of the anti-seizure medication [OR- 0.2 (95% CI: 0.06-0.63)]. Whenever an additional new anti-epileptic drug was prescribed or removed from the pre-existing anti-epileptic medications, it did not significantly impact seizure control.
UNASSIGNED: Individualising drug therapy and therapeutic drug monitoring for each patient, along with patient factors such as medication compliance, concomitant drug and disease history, and pharmacogenetic assessment, should be the ideal practice in patients with seizures for better seizure control.
UNASSIGNED: None declared.
UNASSIGNED: Details of anti-seizure medications with their therapeutic levels in the blood of patients with seizure disorder were analysed.
UNASSIGNED: Hospital-based retrospective analysis of patient case records.
UNASSIGNED: Therapeutic Drug Monitoring OPD of a tertiary care public teaching hospital.
UNASSIGNED: Case records of 918 patients with seizure disorder from 2016-2021.
UNASSIGNED: Data of men (53%) and women (47%) aged between 18-75 years was assessed About 62% (566/918) of patients were on levetiracetam, the most frequently prescribed anti-seizure medication. Whenever the ASMs dose was increased or decreased based on TDM levels, it was associated with a significant increase in the frequency of break-through seizures [OR- 5 (95% CI: 1.28-19.46)]. However, significant seizure control was observed when the patients were on the same maintenance dose of the anti-seizure medication [OR- 0.2 (95% CI: 0.06-0.63)]. Whenever an additional new anti-epileptic drug was prescribed or removed from the pre-existing anti-epileptic medications, it did not significantly impact seizure control.
UNASSIGNED: Individualising drug therapy and therapeutic drug monitoring for each patient, along with patient factors such as medication compliance, concomitant drug and disease history, and pharmacogenetic assessment, should be the ideal practice in patients with seizures for better seizure control.
UNASSIGNED: None declared.
摘要：
■研究目的是评估癫痫患者的处方模式和抗癫痫药物（ASM）的使用，并评估ASM剂量的变化是否对癫痫发作的控制有有益的影响。通过ASM的治疗药物监测[TDM]水平观察。
■分析了癫痫发作患者血液中抗癫痫发作药物及其治疗水平的详细信息。
■基于医院的病例记录回顾性分析。
■三级护理公立教学医院的治疗药物监测OPD。
■2016-2021年918例癫痫患者的病例记录。
■对年龄在18-75岁之间的男性（53％）和女性（47％）的数据进行了评估约62％（566/918）的患者服用左乙拉西坦，最常用的抗癫痫药物。每当ASM剂量根据TDM水平增加或减少时，它与突发性癫痫发作频率显著增加相关[OR-5(95%CI:1.28~19.46)].然而,当患者服用相同维持剂量的抗癫痫药物[OR-0.2(95%CI:0.06~0.63)]时,癫痫发作得到显著控制.每当新的抗癫痫药物被处方或从现有的抗癫痫药物中删除时，它没有显著影响癫痫发作控制.
■对每位患者进行个体化药物治疗和治疗药物监测，以及患者的因素，如药物依从性，伴随药物和疾病史，和药物遗传学评估，应该是癫痫患者更好控制癫痫发作的理想做法。
■没有声明。
■分析了癫痫发作患者血液中抗癫痫发作药物及其治疗水平的详细信息。
■基于医院的病例记录回顾性分析。
■三级护理公立教学医院的治疗药物监测OPD。
■2016-2021年918例癫痫患者的病例记录。
■对年龄在18-75岁之间的男性（53％）和女性（47％）的数据进行了评估约62％（566/918）的患者服用左乙拉西坦，最常用的抗癫痫药物。每当ASM剂量根据TDM水平增加或减少时，它与突发性癫痫发作频率显著增加相关[OR-5(95%CI:1.28~19.46)].然而,当患者服用相同维持剂量的抗癫痫药物[OR-0.2(95%CI:0.06~0.63)]时,癫痫发作得到显著控制.每当新的抗癫痫药物被处方或从现有的抗癫痫药物中删除时，它没有显著影响癫痫发作控制.
■对每位患者进行个体化药物治疗和治疗药物监测，以及患者的因素，如药物依从性，伴随药物和疾病史，和药物遗传学评估，应该是癫痫患者更好控制癫痫发作的理想做法。
■没有声明。
