PDF(Pubmed)
Abstract：
There is a large pool of ideas in both mainstream and non-mainstream medicine on how diet can be manipulated in order to treat or prevent illnesses. Despite this, our understanding of how specific changes in diet influence the structure and function of the gastrointestinal tract is limited. This review aims to describe two areas that might provide key information on the integrity and function of the gastrointestinal tract. First, demystifying the \"leaky gut syndrome\" requires rational application and interpretation of tests of intestinal barrier function. Multiple ways of measuring barrier function have been described, but the inherent difficulties in translation from animal studies to humans have created misinterpretations and misconceptions. The intrinsic nature of intestinal barrier function is dynamic. This is seldom considered in studies of intestinal barrier assessment. To adequately understand the effects of dietary interventions on intestinal barrier function, background barrier function in different regions of the gut and the dynamic responses to stressors (such as psychological stress) should be assessed as a minimum. Second, intestinal ultrasound, which is now established in the assessment and monitoring of inflammatory bowel disease, has hitherto been poorly evaluated in assessing real-time intestinal function and novel aspects of structure in patients with disorders of gut-brain interaction. In conclusion, a more complete functional and structural profile that these investigations enable should permit a greater understanding of the effects of dietary manipulation on the gastrointestinal tract and provide clinically relevant information that, amongst other advantages, might permit opportunities for personalized health care delivery.
摘要：
在主流和非主流医学中，有很多关于如何控制饮食以治疗或预防疾病的想法。尽管如此,我们对饮食的具体变化如何影响胃肠道的结构和功能的理解是有限的。这篇综述旨在描述两个可能提供有关胃肠道完整性和功能的关键信息的领域。首先,揭开“肠漏综合征”的神秘面纱需要合理应用和解释肠道屏障功能的测试。已经描述了多种测量屏障功能的方法，但是从动物研究到人类翻译的固有困难造成了误解和误解。肠屏障功能的内在本质是动态的。在肠屏障评估的研究中很少考虑这一点。为了充分了解饮食干预对肠屏障功能的影响，肠道不同区域的背景屏障功能和对应激源（如心理压力）的动态反应应被评估为最低限度。第二,肠道超声，现在建立在炎症性肠病的评估和监测中，迄今为止，在评估肠-脑相互作用障碍患者的实时肠功能和新结构方面的评估很少。总之,一个更完整的功能和结构概况，这些研究使应该允许更好地了解饮食操作对胃肠道的影响，并提供临床相关信息，除其他优势外，可能允许个性化医疗保健提供的机会。
