PDF(Pubmed)
Abstract：
The medicinal plant Bredemeyera floribunda Willd. is used to treat cardiovascular disease, chronic fatigue, low libido, as well as increased diuresis. However, studies considering the toxicity of this plant are scarce. Develop an aqueous extract of B. floribunda considering traditional use and determine the average lethality (LD50), signs, and symptoms of toxicity. The B. floribunda extract was obtained by immersing the root bark in ultrapure water for 18 hours at 4°C, under constant stirring. The test extract was administered in a single dose of 2.000 mg/kg by gavage to rats. Signs and symptoms of toxicity were determined according to the Hippocratic screening test and compared with the control group. In addition, a necropsy was performed for macroscopic evaluation of the organs in the abdominal cavity. A powder was obtained from aqueous extracts that showed the same organoleptic characteristics and emulsification capacity as those presented by the fresh root when prepared according to popular tradition. The LD50 was greater than the test dose with three animals surviving. On the other hand, necropsy of dead rats showed necrosis and reduction in lung mass, in addition to the presence of foam and excessive distension of the stomach and intestines. The main symptoms of toxicity were anesthesia, ataxia, sedation, loss of muscle strength, and excessive drowsiness in the first 24 hours. There was no difference between the control and extract groups with regard to body mass, food, and water intake, as well as in macroscopy of the heart, liver, lungs, intestines, spleen, pancreas, and kidneys. The aqueous extract of the B. floribunda was considered nontoxic or of very low toxicity. However, it is capable of altering the activity of the central nervous system and causing disorders in the respiratory and digestive systems.
摘要：
药用植物BredemeyerafloribundaWilld。用于治疗心血管疾病，慢性疲劳,性欲低下,以及增加利尿。然而,考虑到这种植物毒性的研究很少。开发B.floribunda考虑传统用途的水提取物，并确定平均致死率（LD50），标志,和毒性症状。通过在4°C下将根皮浸入超纯水中18小时来获得B.floribunda提取物，在不断搅拌下。通过管饲法以2.000mg/kg的单剂量向大鼠施用测试提取物。根据希波克拉底筛查试验确定毒性的体征和症状，并与对照组进行比较。此外,进行尸检以对腹腔内器官进行宏观评估.从根据流行传统制备的水提取物中获得粉末，其显示出与新鲜根相同的感官特征和乳化能力。LD50大于三只动物存活的测试剂量。另一方面,死亡大鼠的尸检显示坏死和肺肿块减少，除了存在泡沫和过度扩张的胃和肠。毒性的主要症状是麻醉，共济失调,镇静,肌肉力量的丧失,在最初的24小时内过度嗜睡。在体重方面，对照组和提取物组之间没有差异，食物,和水的摄入，以及心脏的宏观，肝脏,肺,肠子,脾,脾胰腺,还有肾脏.该花双歧杆菌的水提取物被认为是无毒的或具有非常低的毒性。然而,它能够改变中枢神经系统的活动，并引起呼吸和消化系统的紊乱。
