PDF(Pubmed)
Abstract：
UNASSIGNED: In this study, the association between the monocyte-to-high-density lipoprotein cholesterol ratio (MHR) at diagnosis and poor outcomes of atherosclerosis-related antineutrophil cytoplasmic antibody-associated vasculitis (AAV) during follow-up in patients with AAV was investigated.
UNASSIGNED: This retrospective study included 138 patients diagnosed with AAV. Their comprehensive medical records were meticulously reviewed. All-cause mortality, cerebrovascular accident (CVA), and acute coronary syndrome (ACS) were evaluated as atherosclerosis-related poor outcomes of AAV. MHR was obtained by dividing monocyte counts (/mm3) by high-density lipoprotein cholesterol (mg/dL) levels.
UNASSIGNED: The median age of the 138 patients was 58.3 years with 44 being male (31.9%). Among the 138 patients, 11 (8.0%) died, and 11 (8.0%) and 9 (6.5%) had CVA, and ACS, respectively. MHR at diagnosis was significantly correlated with the Birmingham vasculitis activity score, erythrocyte sedimentation rate, and C-reactive protein at diagnosis. Among the three poor outcomes of AAV, only CVA during follow-up was significantly associated with MHR at diagnosis, and thus, only CVA was considered an atherosclerosis-related poor outcome of AAV. In the multivariable Cox hazards model analysis, MHR (hazard ratio [HR] 1.195) and serum albumin (HR 0.203) at diagnosis were independently associated with CVA during follow-up. Additionally, patients with MHR at diagnosis ≥3.0 exhibited a significantly higher risk for CVA and lower cumulative CVA-free survival rate than those with MHR at diagnosis <3.0.
UNASSIGNED: This study is the first to demonstrate clinical implications of MHR suggesting that MHR at diagnosis is significantly and independently associated with CVA during follow-up in patients with AAV.
UNASSIGNED: This retrospective study included 138 patients diagnosed with AAV. Their comprehensive medical records were meticulously reviewed. All-cause mortality, cerebrovascular accident (CVA), and acute coronary syndrome (ACS) were evaluated as atherosclerosis-related poor outcomes of AAV. MHR was obtained by dividing monocyte counts (/mm3) by high-density lipoprotein cholesterol (mg/dL) levels.
UNASSIGNED: The median age of the 138 patients was 58.3 years with 44 being male (31.9%). Among the 138 patients, 11 (8.0%) died, and 11 (8.0%) and 9 (6.5%) had CVA, and ACS, respectively. MHR at diagnosis was significantly correlated with the Birmingham vasculitis activity score, erythrocyte sedimentation rate, and C-reactive protein at diagnosis. Among the three poor outcomes of AAV, only CVA during follow-up was significantly associated with MHR at diagnosis, and thus, only CVA was considered an atherosclerosis-related poor outcome of AAV. In the multivariable Cox hazards model analysis, MHR (hazard ratio [HR] 1.195) and serum albumin (HR 0.203) at diagnosis were independently associated with CVA during follow-up. Additionally, patients with MHR at diagnosis ≥3.0 exhibited a significantly higher risk for CVA and lower cumulative CVA-free survival rate than those with MHR at diagnosis <3.0.
UNASSIGNED: This study is the first to demonstrate clinical implications of MHR suggesting that MHR at diagnosis is significantly and independently associated with CVA during follow-up in patients with AAV.
摘要：
■在这项研究中，本研究对AAV患者诊断时的单核细胞与高密度脂蛋白胆固醇比值(MHR)与随访期间动脉粥样硬化相关的抗中性粒细胞胞浆抗体相关性血管炎(AAV)不良结局之间的关系进行了研究.
■这项回顾性研究包括138例诊断为AAV的患者。他们的全面医疗记录被仔细审查。全因死亡率,脑血管意外（CVA），和急性冠脉综合征（ACS）被评估为与动脉粥样硬化相关的AAV不良结局。通过将单核细胞计数(/mm3)除以高密度脂蛋白胆固醇(mg/dL)水平获得MHR。
■138例患者的中位年龄为58.3岁，其中44例为男性（31.9%）。在138名患者中，11人（8.0%）死亡，11例(8.0%)和9例(6.5%)有CVA，ACS,分别。诊断时MHR与伯明翰血管炎活动评分显著相关，红细胞沉降率,和C反应蛋白在诊断时。在AAV的三个不良结果中，只有随访期间的CVA与诊断时的MHR显著相关，因此，只有CVA被认为是与动脉粥样硬化相关的AAV不良结局.在多变量Cox风险模型分析中，诊断时的MHR（风险比[HR]1.195）和血清白蛋白（HR0.203）与随访期间的CVA独立相关。此外,与诊断<3.0时的MHR患者相比,诊断≥3.0时的MHR患者出现CVA的风险显著较高,且无CVA累积生存率较低.
■这项研究首次证明了MHR的临床意义，表明在AAV患者的随访期间，MHR在诊断时与CVA显着且独立相关。
■这项回顾性研究包括138例诊断为AAV的患者。他们的全面医疗记录被仔细审查。全因死亡率,脑血管意外（CVA），和急性冠脉综合征（ACS）被评估为与动脉粥样硬化相关的AAV不良结局。通过将单核细胞计数(/mm3)除以高密度脂蛋白胆固醇(mg/dL)水平获得MHR。
■138例患者的中位年龄为58.3岁，其中44例为男性（31.9%）。在138名患者中，11人（8.0%）死亡，11例(8.0%)和9例(6.5%)有CVA，ACS,分别。诊断时MHR与伯明翰血管炎活动评分显著相关，红细胞沉降率,和C反应蛋白在诊断时。在AAV的三个不良结果中，只有随访期间的CVA与诊断时的MHR显著相关，因此，只有CVA被认为是与动脉粥样硬化相关的AAV不良结局.在多变量Cox风险模型分析中，诊断时的MHR（风险比[HR]1.195）和血清白蛋白（HR0.203）与随访期间的CVA独立相关。此外,与诊断<3.0时的MHR患者相比,诊断≥3.0时的MHR患者出现CVA的风险显著较高,且无CVA累积生存率较低.
■这项研究首次证明了MHR的临床意义，表明在AAV患者的随访期间，MHR在诊断时与CVA显着且独立相关。
