Abstract：
Wounds represent a growing global issue demanding increased attention. To expedite wound healing, technologies are under development, and light emitting diode (LED) devices of varying wavelengths are being explored for their stimulating influence on the healing process. This article presents a systematic literature review aiming to compile, organize, and analyze the impacts of LED devices on wound healing. This review is registered on the PROSPERO platform [CRD42023403870]. Two blinded authors conducted searches in the Pubmed, Web of Science, Scopus, Embase, and ScienceDirect databases. In vitro and in vivo experimental studies assessing LED utilization in the wound healing process were included. The search yielded 1010 studies, of which 27 were included in the review. It was identified that LED stimulates different healing pathways, promoting enhanced cell proliferation and migration, angiogenesis stimulation, increased collagen deposition, and modulation of the inflammatory response. Thus, it can be concluded that the LED stimulates cellular and molecular processes contingent on the utilized parameters. The effects depend on the standards used. Cell migration and proliferation were better influenced by green and red LED. The extracellular matrix components and angiogenesis were regulated by all wavelengths and the modulation of inflammation was mediated by green, red, and infrared LEDs.
摘要：
伤口是一个日益增长的全球性问题，需要更多的关注。为了加快伤口愈合，技术正在开发中，和不同波长的发光二极管（LED）设备正在探索它们对愈合过程的刺激影响。本文提出了一个系统的文献综述，旨在汇编，组织,分析LED器件对伤口愈合的影响。此评论已在PROSPERO平台[CRD42023403870]上注册。两名失明的作者在Pubmed中进行了搜索，WebofScience,Scopus,Embase,和ScienceDirect数据库。包括评估伤口愈合过程中LED利用率的体外和体内实验研究。搜索产生了1010项研究，其中27人被列入审查范围。发现LED刺激不同的愈合途径，促进细胞增殖和迁移，血管生成刺激,胶原蛋白沉积增加，和炎症反应的调节。因此，可以得出结论，LED刺激细胞和分子过程取决于所使用的参数。效果取决于所使用的标准。绿色和红色LED对细胞迁移和增殖的影响较好。细胞外基质成分和血管生成受所有波长的调节，炎症的调节由绿色，红色,和红外LED。
