Abstract：
UNASSIGNED: Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic disorders in women of reproductive age. It is frequently comorbid with obesity and negative emotions. Currently, there are few reports on the relationship between obesity and negative emotions in patients with PCOS. Here we performed both basic and clinical studies to study the relationship between obesity and negative emotions in PCOS.
UNASSIGNED: We performed a cross-sectional study including 608 patients with PCOS and 184 healthy participants to assess the mental health status of people with different body mass indices (BMI). Self-rated anxiety, depression, and perceived stress scales were used for subjective mood evaluations. Rat PCOS models fed 45 and 60% high-fat diets were used to confirm the results of the clinical study. Elevated plus maze and open field tests were used to assess anxiety- and depression-like behaviors in rats.
UNASSIGNED: We observed overweight/obesity, increased depression, anxiety, and perceived stress in women with PCOS, and found that anxiety and depression were negatively correlated with BMI in patients with severe obesity and PCOS. Similar results were confirmed in the animal study; the elevated plus maze test and open field test demonstrated that only 60% of high fat diet-induced obesity partly reversed anxiety- and depression-like behaviors in PCOS rats. A high-fat diet also modulated rat hypothalamic and hippocampal luteinizing hormone and testosterone levels.
UNASSIGNED: These results reveal a potential relationship between obesity and negative emotions in PCOS and prompt further investigation. The interactions between various symptoms of PCOS may be targeted to improve the overall well-being of patients.
Obesity was negatively correlated with negative emotions in patients with PCOS.Obesity may affect the downregulation of LH and testosterone and participate in the regulation of emotions.Increased BMI may be beneficial for patients with PCOS in terms of the psychological aspects.
UNASSIGNED: We performed a cross-sectional study including 608 patients with PCOS and 184 healthy participants to assess the mental health status of people with different body mass indices (BMI). Self-rated anxiety, depression, and perceived stress scales were used for subjective mood evaluations. Rat PCOS models fed 45 and 60% high-fat diets were used to confirm the results of the clinical study. Elevated plus maze and open field tests were used to assess anxiety- and depression-like behaviors in rats.
UNASSIGNED: We observed overweight/obesity, increased depression, anxiety, and perceived stress in women with PCOS, and found that anxiety and depression were negatively correlated with BMI in patients with severe obesity and PCOS. Similar results were confirmed in the animal study; the elevated plus maze test and open field test demonstrated that only 60% of high fat diet-induced obesity partly reversed anxiety- and depression-like behaviors in PCOS rats. A high-fat diet also modulated rat hypothalamic and hippocampal luteinizing hormone and testosterone levels.
UNASSIGNED: These results reveal a potential relationship between obesity and negative emotions in PCOS and prompt further investigation. The interactions between various symptoms of PCOS may be targeted to improve the overall well-being of patients.
Obesity was negatively correlated with negative emotions in patients with PCOS.Obesity may affect the downregulation of LH and testosterone and participate in the regulation of emotions.Increased BMI may be beneficial for patients with PCOS in terms of the psychological aspects.
摘要：
■多囊卵巢综合征（PCOS）是育龄妇女中最常见的内分泌和代谢紊乱之一。它经常与肥胖和负面情绪并存。目前,关于PCOS患者肥胖与负性情绪关系的报道较少。在这里，我们进行了基础和临床研究，以研究PCOS中肥胖与负面情绪之间的关系。
■我们进行了一项横断面研究，包括608名PCOS患者和184名健康参与者，以评估具有不同体重指数（BMI）的人的心理健康状况。自我评估的焦虑，抑郁症,感知压力量表用于主观情绪评估。饲喂45%和60%高脂肪饮食的大鼠PCOS模型用于证实临床研究的结果。使用高架迷宫和空场测试来评估大鼠的焦虑和抑郁样行为。
■我们观察到超重/肥胖，抑郁症加重,焦虑,以及PCOS女性的感知压力，发现重度肥胖和PCOS患者的焦虑和抑郁与BMI呈负相关。在动物研究中证实了类似的结果；升高的迷宫试验和野外试验表明，只有60％的高脂饮食诱导的肥胖部分逆转了PCOS大鼠的焦虑和抑郁样行为。高脂饮食还可以调节大鼠下丘脑和海马黄体生成素和睾丸激素水平。
■这些结果揭示了PCOS患者肥胖与负面情绪之间的潜在关系，并促使进一步调查。PCOS的各种症状之间的相互作用可能是有针对性的，以改善患者的整体健康状况。
PCOS患者肥胖与负性情绪呈负相关。肥胖可能影响LH和睾酮的下调,参与情绪调节。在心理方面，增加的BMI可能对PCOS患者有益。
■我们进行了一项横断面研究，包括608名PCOS患者和184名健康参与者，以评估具有不同体重指数（BMI）的人的心理健康状况。自我评估的焦虑，抑郁症,感知压力量表用于主观情绪评估。饲喂45%和60%高脂肪饮食的大鼠PCOS模型用于证实临床研究的结果。使用高架迷宫和空场测试来评估大鼠的焦虑和抑郁样行为。
■我们观察到超重/肥胖，抑郁症加重,焦虑,以及PCOS女性的感知压力，发现重度肥胖和PCOS患者的焦虑和抑郁与BMI呈负相关。在动物研究中证实了类似的结果；升高的迷宫试验和野外试验表明，只有60％的高脂饮食诱导的肥胖部分逆转了PCOS大鼠的焦虑和抑郁样行为。高脂饮食还可以调节大鼠下丘脑和海马黄体生成素和睾丸激素水平。
■这些结果揭示了PCOS患者肥胖与负面情绪之间的潜在关系，并促使进一步调查。PCOS的各种症状之间的相互作用可能是有针对性的，以改善患者的整体健康状况。
PCOS患者肥胖与负性情绪呈负相关。肥胖可能影响LH和睾酮的下调,参与情绪调节。在心理方面，增加的BMI可能对PCOS患者有益。
