PDF(Pubmed)
Abstract：
OBJECTIVE: Stroke damage to the primary visual cortex induces large, homonymous visual field defects that impair daily living. Here, we asked if vision-related quality of life (VR-QoL) is impacted by time since stroke.
METHODS: We conducted a retrospective meta-analysis of 95 occipital stroke patients (female/male = 26/69, 27-78 years old, 0.5-373.5 months poststroke) in whom VR-QoL was estimated using the National Eye Institute Visual Functioning Questionnaire (NEI-VFQ) and its 10-item neuro-ophthalmic supplement (Neuro10). Visual deficit severity was represented by the perimetric mean deviation (PMD) calculated from 24-2 Humphrey visual fields. Data were compared with published cohorts of visually intact controls. The relationship between VR-QoL and time poststroke was assessed across participants, adjusting for deficit severity and age with a multiple linear regression analysis.
RESULTS: Occipital stroke patients had significantly lower NEI-VFQ and Neuro10 composite scores than controls. All subscale scores describing specific aspects of visual ability and functioning were impaired except for ocular pain and general health, which did not differ significantly from controls. Surprisingly, visual deficit severity was not correlated with either composite score, both of which increased with time poststroke, even when adjusting for PMD and age.
CONCLUSIONS: VR-QoL appears to improve with time postoccipital stroke, irrespective of visual deficit size or patient age at insult. This may reflect the natural development of compensatory strategies and lifestyle adjustments. Thus, future studies examining the impact of rehabilitation on daily living in this patient population should consider the possibility that their VR-QoL may change gradually over time, even without therapeutic intervention.
METHODS: We conducted a retrospective meta-analysis of 95 occipital stroke patients (female/male = 26/69, 27-78 years old, 0.5-373.5 months poststroke) in whom VR-QoL was estimated using the National Eye Institute Visual Functioning Questionnaire (NEI-VFQ) and its 10-item neuro-ophthalmic supplement (Neuro10). Visual deficit severity was represented by the perimetric mean deviation (PMD) calculated from 24-2 Humphrey visual fields. Data were compared with published cohorts of visually intact controls. The relationship between VR-QoL and time poststroke was assessed across participants, adjusting for deficit severity and age with a multiple linear regression analysis.
RESULTS: Occipital stroke patients had significantly lower NEI-VFQ and Neuro10 composite scores than controls. All subscale scores describing specific aspects of visual ability and functioning were impaired except for ocular pain and general health, which did not differ significantly from controls. Surprisingly, visual deficit severity was not correlated with either composite score, both of which increased with time poststroke, even when adjusting for PMD and age.
CONCLUSIONS: VR-QoL appears to improve with time postoccipital stroke, irrespective of visual deficit size or patient age at insult. This may reflect the natural development of compensatory strategies and lifestyle adjustments. Thus, future studies examining the impact of rehabilitation on daily living in this patient population should consider the possibility that their VR-QoL may change gradually over time, even without therapeutic intervention.
摘要：
目的：中风对初级视觉皮层的损伤影响日常生活的同义视野缺陷。这里,我们询问视觉相关生活质量(VR-QoL)是否受卒中后时间的影响.
方法：我们对95例枕骨卒中患者（女性/男性=26/69，27-78岁，中风后0.5-373.5个月）使用国家眼科研究所视觉功能问卷（NEI-VFQ）及其10项神经眼科补充剂（Neuro10）估算VR-QoL。视觉缺陷的严重程度由从24-2汉弗莱视野计算的周边平均偏差（PMD）表示。将数据与已发表的视觉上完整的对照组进行比较。在参与者中评估VR-QoL与卒中后时间之间的关系，用多元线性回归分析调整缺陷严重程度和年龄。
结果：枕骨卒中患者的NEI-VFQ和Neuro10综合评分明显低于对照组。描述视觉能力和功能的特定方面的所有子量表得分均受损，除了眼部疼痛和一般健康状况，与对照组没有显着差异。令人惊讶的是,视力缺损严重程度与任一综合评分均无相关性，两者都随着中风后的时间而增加，即使在调整PMD和年龄。
结论：VR-QoL似乎随着枕骨卒中后时间的增加而改善，无论视力缺陷大小或患者年龄在侮辱。这可能反映了补偿性策略和生活方式调整的自然发展。因此，未来的研究检查康复对该患者人群日常生活的影响，应该考虑他们的VR-QoL可能随着时间的推移而逐渐变化的可能性，即使没有治疗干预。
方法：我们对95例枕骨卒中患者（女性/男性=26/69，27-78岁，中风后0.5-373.5个月）使用国家眼科研究所视觉功能问卷（NEI-VFQ）及其10项神经眼科补充剂（Neuro10）估算VR-QoL。视觉缺陷的严重程度由从24-2汉弗莱视野计算的周边平均偏差（PMD）表示。将数据与已发表的视觉上完整的对照组进行比较。在参与者中评估VR-QoL与卒中后时间之间的关系，用多元线性回归分析调整缺陷严重程度和年龄。
结果：枕骨卒中患者的NEI-VFQ和Neuro10综合评分明显低于对照组。描述视觉能力和功能的特定方面的所有子量表得分均受损，除了眼部疼痛和一般健康状况，与对照组没有显着差异。令人惊讶的是,视力缺损严重程度与任一综合评分均无相关性，两者都随着中风后的时间而增加，即使在调整PMD和年龄。
结论：VR-QoL似乎随着枕骨卒中后时间的增加而改善，无论视力缺陷大小或患者年龄在侮辱。这可能反映了补偿性策略和生活方式调整的自然发展。因此，未来的研究检查康复对该患者人群日常生活的影响，应该考虑他们的VR-QoL可能随着时间的推移而逐渐变化的可能性，即使没有治疗干预。
