PDF(Pubmed)
Abstract：
BACKGROUND: Platelets are critical in maintaining homeostasis and immune response in burn patients. The concentration of platelets decreases in burn patients, and any intervention that increases serum platelet concentration can prevent serious consequences and patient death. The present study aimed to assess the impact of skin graft surgery on burn patients\' platelet counts.
METHODS: In this non-randomized clinical trial, 200 burn patients were investigated. The patients were recruited from the surgical ward of Imam Khomeini Teaching Hospital during the first six months of 2021. After completing the checklist, patients underwent skin graft surgery. Blood was taken from the patients during surgery in the operating room and on the third and fifth day after the surgery to check platelets. Data analysis was conducted using SPSS software (ver. 22.0).
RESULTS: Most patients (63.5%) were male, and 73 (36.5%) were female. One hundred eighty-one patients (90.5%) had deep burns, and 19 (9.5%) had superficial burns. The mean burns percentage in the patients was 19.3 ± 15.4%, the lowest was 2%, and the highest was 90%. The most common burns were caused by flame (42%) and boiling water (30.5%). The patients\' outcomes revealed that 6% gained complete recovery, 86.5% partial recovery, 2.5% showed transplant rejection, and 5% died. Mean platelet levels in deceased patients had an upward trend. The mean platelet counts of patients were elevated during surgery (289,855 ± 165,378), decreased three days after surgery (282,778 ± 317,310), and elevated again five days after surgery (330,375 ± 208,571). However, no significant difference was found between the mean platelet counts during surgery, the third and fifth days after surgery in patients undergoing skin grafts (P = 0.057).
CONCLUSIONS: This study suggests that skin graft positively increases the patient\'s platelets. Further studies are needed to confirm the findings and elucidate the mechanism. Iranian Registry of Clinical Trial approval code (IRCT# IRCT20131112015390N8 & 06/01/2024).
METHODS: In this non-randomized clinical trial, 200 burn patients were investigated. The patients were recruited from the surgical ward of Imam Khomeini Teaching Hospital during the first six months of 2021. After completing the checklist, patients underwent skin graft surgery. Blood was taken from the patients during surgery in the operating room and on the third and fifth day after the surgery to check platelets. Data analysis was conducted using SPSS software (ver. 22.0).
RESULTS: Most patients (63.5%) were male, and 73 (36.5%) were female. One hundred eighty-one patients (90.5%) had deep burns, and 19 (9.5%) had superficial burns. The mean burns percentage in the patients was 19.3 ± 15.4%, the lowest was 2%, and the highest was 90%. The most common burns were caused by flame (42%) and boiling water (30.5%). The patients\' outcomes revealed that 6% gained complete recovery, 86.5% partial recovery, 2.5% showed transplant rejection, and 5% died. Mean platelet levels in deceased patients had an upward trend. The mean platelet counts of patients were elevated during surgery (289,855 ± 165,378), decreased three days after surgery (282,778 ± 317,310), and elevated again five days after surgery (330,375 ± 208,571). However, no significant difference was found between the mean platelet counts during surgery, the third and fifth days after surgery in patients undergoing skin grafts (P = 0.057).
CONCLUSIONS: This study suggests that skin graft positively increases the patient\'s platelets. Further studies are needed to confirm the findings and elucidate the mechanism. Iranian Registry of Clinical Trial approval code (IRCT# IRCT20131112015390N8 & 06/01/2024).
摘要：
背景：血小板对于维持烧伤患者的体内平衡和免疫反应至关重要。烧伤患者的血小板浓度降低，任何增加血清血小板浓度的干预措施都可以防止严重后果和患者死亡。本研究旨在评估皮肤移植手术对烧伤患者血小板计数的影响。
方法：在这项非随机临床试验中，调查了200名烧伤患者。这些患者是在2021年的前六个月从伊玛目霍梅尼教学医院的手术室招募的。完成检查表后,患者接受植皮手术。在手术室手术期间以及手术后的第3天和第5天从患者身上抽取血液以检查血小板。数据分析采用SPSS软件(ver.22.0).
结果：大多数患者（63.5%）为男性，73人(36.5%)为女性。一百八十一名患者(90.5%)有深度烧伤,19例(9.5%)有浅表烧伤。患者的平均烧伤百分比为19.3±15.4％，最低的是2%,最高的是90%。最常见的烧伤是由火焰（42％）和沸水（30.5％）引起的。结果显示，6%的患者获得了完全康复，部分回收率86.5%，2.5%显示移植排斥,5%的人死亡。死亡患者的平均血小板水平呈上升趋势。患者术中平均血小板计数升高(289,855±165,378),术后三天下降(282,778±317,310)，术后五天再次升高（330,375±208,571）。然而,手术期间平均血小板计数之间没有发现显着差异，术后第3天和第5天接受皮肤移植的患者（P=0.057）。
结论：这项研究表明，皮肤移植能积极增加患者的血小板。需要进一步的研究来证实这些发现并阐明其机制。伊朗注册临床试验批准代码（IRCT#IRCT20131112015390N8&06/01/2024）。
方法：在这项非随机临床试验中，调查了200名烧伤患者。这些患者是在2021年的前六个月从伊玛目霍梅尼教学医院的手术室招募的。完成检查表后,患者接受植皮手术。在手术室手术期间以及手术后的第3天和第5天从患者身上抽取血液以检查血小板。数据分析采用SPSS软件(ver.22.0).
结果：大多数患者（63.5%）为男性，73人(36.5%)为女性。一百八十一名患者(90.5%)有深度烧伤,19例(9.5%)有浅表烧伤。患者的平均烧伤百分比为19.3±15.4％，最低的是2%,最高的是90%。最常见的烧伤是由火焰（42％）和沸水（30.5％）引起的。结果显示，6%的患者获得了完全康复，部分回收率86.5%，2.5%显示移植排斥,5%的人死亡。死亡患者的平均血小板水平呈上升趋势。患者术中平均血小板计数升高(289,855±165,378),术后三天下降(282,778±317,310)，术后五天再次升高（330,375±208,571）。然而,手术期间平均血小板计数之间没有发现显着差异，术后第3天和第5天接受皮肤移植的患者（P=0.057）。
结论：这项研究表明，皮肤移植能积极增加患者的血小板。需要进一步的研究来证实这些发现并阐明其机制。伊朗注册临床试验批准代码（IRCT#IRCT20131112015390N8&06/01/2024）。
