PDF(Pubmed)
Abstract：
Our study aimed to investigate the relationship between sleep-wake changes and depressive symptoms events among midlife women. We enrolled 1579 women aged 44-56 years who had no clinically relevant depressive symptoms at baseline. Depressive symptoms were assessed at each visit using the Center for Epidemiologic Studies Depression scale. At the third and fourth follow-up visits, women reported their sleep habits. The sleep midpoint was defined as the time to fall asleep plus one-half of the sleep duration. Sleep-wake changes were determined by the difference in the midpoint of sleep between the third and fourth visits, which were 1 year apart. The median follow-up time was 7 years (range 1-7 years). Cox proportional hazard models were fitted to calculate hazard ratios and 95% confidence intervals for the incidence of depressive symptoms associated with sleep-wake changes. After adjusting for potential confounding factors, the hazard ratio (95% confidence interval) of depressive symptoms for severe sleep midpoint changes was 1.51 (1.12, 2.05) compared with mild sleep midpoint changes. This relationship remained statistically significant and changed little when additionally controlling for sleep duration, sleep quality, insomnia symptoms, use of sleep medications, use of nervous medications, glucose, insulin, lipids, dietary energy intake, and C-reactive protein. Our findings indicate that exposure to long-term severe sleep-wake changes increases the risk of depressive symptoms in midlife women.
摘要：
我们的研究旨在调查中年女性的睡眠-觉醒变化与抑郁症状事件之间的关系。我们招募了1579名年龄在44-56岁之间的女性，这些女性在基线时没有临床相关的抑郁症状。每次就诊时使用流行病学研究中心抑郁量表评估抑郁症状。在第三次和第四次后续访问中,妇女报告他们的睡眠习惯。睡眠中点定义为入睡时间加上睡眠持续时间的一半。睡眠-觉醒变化是由第三次和第四次访问之间睡眠中点的差异决定的。相隔一年。中位随访时间为7年（范围1-7年）。拟合Cox比例风险模型，以计算与睡眠-觉醒变化相关的抑郁症状发生率的风险比和95％置信区间。在调整了潜在的混杂因素后，重度睡眠中点变化与轻度睡眠中点变化相比,抑郁症状的风险比(95%置信区间)为1.51(1.12,2.05).这种关系仍然具有统计学意义，并且在另外控制睡眠持续时间时变化不大。睡眠质量,失眠症状,使用睡眠药物，使用紧张的药物，葡萄糖，胰岛素，脂质，膳食能量摄入，和C反应蛋白.我们的发现表明，长期暴露于严重的睡眠-觉醒变化会增加中年女性抑郁症状的风险。
