PDF(Pubmed)
Abstract：
The meninges are critical for the brain functions, but the diversity of meningeal cell types and intercellular interactions have yet to be thoroughly examined. Here we identify a population of meningeal lymphatic supporting cells (mLSCs) in the zebrafish leptomeninges, which are specifically labeled by ependymin. Morphologically, mLSCs form membranous structures that enwrap the majority of leptomeningeal blood vessels and all the mural lymphatic endothelial cells (muLECs). Based on its unique cellular morphologies and transcriptional profile, mLSC is characterized as a unique cell type different from all the currently known meningeal cell types. Because of the formation of supportive structures and production of pro-lymphangiogenic factors, mLSCs not only promote muLEC development and maintain the dispersed distributions of muLECs in the leptomeninges, but also are required for muLEC regeneration after ablation. This study characterizes a newly identified cell type in leptomeninges, mLSC, which is required for muLEC development, maintenance, and regeneration.
摘要：
脑膜对大脑功能至关重要，但是脑膜细胞类型和细胞间相互作用的多样性尚未得到彻底检查。在这里，我们确定了斑马鱼软脑膜中的脑膜淋巴支持细胞（mLSCs）群体，它们被专门标记为ependymin。形态学上,mLSCs形成包裹大部分软脑膜血管和所有壁淋巴管内皮细胞(muLEC)的膜结构。基于其独特的细胞形态和转录谱，mLSC被表征为不同于所有目前已知的脑膜细胞类型的独特细胞类型。由于支持结构的形成和淋巴管生成因子的产生，mLSCs不仅促进muLEC发育，而且维持muLEC在软脑膜中的分散分布，但也需要在消融后进行muLEC再生。这项研究描述了一种新发现的软脑膜细胞类型，mLSC,这是muLEC开发所需要的，维护,和再生。
