Abstract：
Objective: To observe the impact of implantable Collamer lens (ICL) implantation surgery on choroidal thickness and blood flow density in myopic patients. Methods: This was a prospective cohort study. Patients undergoing ICL surgery at Qingdao University Affiliated Hospital between June 2021 and May 2023 were consecutively enrolled. Patients were categorized into high myopia (HM) and super high myopia (SHM) groups based on whether their spherical equivalence power exceeded 10.00 D. Comprehensive ophthalmic examinations, including optical coherence tomography, optical coherence tomography angiography, visual acuity assessment, intraocular pressure measurement, and optometry, were performed preoperatively and at 1 week, 1 month, and 3 months postoperatively. Results: A total of 42 patients (84 eyes), with an average age of (25.27±3.18) years, comprising 11 males and 31 females, were enrolled in the study. Among them, 20 patients belonged to the HM group, while 22 patients were in the SHM group. Both choroidal thickness and blood flow density exhibited significant increases at postoperative 1 week and 1 month compared to preoperative levels (P<0.05), but returned to baseline levels by postoperative 3 months. Specifically, the subfoveal choroidal thickness increased from (169.49±61.57) μm preoperatively to (180.16±66.61) μm at 1 week, (186.69±63.32) μm at 1 month, and then reverted to (169.58±60.82) μm at 3 months. The central choroidal blood flow density showed changes from 60.03%±1.60% preoperatively to 61.04%±1.17% at 1 week, 60.42%±1.81% at 1 month, and 60.22%±1.57% at 3 months. Furthermore, the HM group exhibited more pronounced changes in both choroidal thickness and blood flow density across all time points compared to the SHM group. Significant differences were observed in choroidal thickness changes at various areas at 1 month, while changes in blood flow density in specific areas were significant. However, no significant differences were noted at 3 months postoperatively. Correlation analysis revealed a negative correlation of changes in subfoveal choroidal thickness and central choroidal blood flow density postoperatively at 1 week and 3 months with preoperative choroidal blood flow density. Notably, no correlation was found between preoperative choroidal thickness and postoperative changes. Conclusions: In the early period following ICL implantation, the increase in choroidal thickness and blood flow density may be more pronounced in HM compared to SHM, but the two parameters can return to baseline levels by 3 months. ICL implantation transiently affects the fundus microenvironment in myopic patients, with implications of preoperative choroidal blood flow.
目的： 观察有晶状体眼植入式Collamer透镜（ICL）植入术对近视眼患者脉络膜厚度及血流密度的影响。 方法： 前瞻性队列研究。连续收集2021年6月至2023年5月在青岛大学附属医院眼科确诊为屈光不正并行ICL植入术的患者。根据患者术前近视等效球镜度数是否大于10.00 D，分为高度近视眼（HM）组和超高度近视眼（SHM）组。所有患者均于术前及术后1周、1个月、3个月行相干光层析成像术、相干光层析血管成像术及其他眼科常规检查如视力、眼压、验光等。 结果： 共纳入患者42例（84只眼），年龄（25.27±3.18）岁，男性11例，女性31例。其中HM组20例，SHM组22例。患者术后1周、1个月的脉络膜厚度和血流密度均较术前显著增高（P<0.05），术后3个月恢复至术前水平［术前及术后1周、1个月和3个月，黄斑中心凹下脉络膜厚度分别为（169.49±61.57）、（180.16±66.61）（186.69±63.32）、（169.58±60.82）μm；中央区脉络膜血流密度分别为60.03%±1.60%、61.04%±1.17%、60.42%±1.81%、60.22%±1.57%］。术后1周和1个月，HM组各方向脉络膜厚度及血流密度变化值高于SHM组，1周时两组间脉络膜厚度变化值在内环颞区［（12.20±10.79）、（6.71±9.89）μm］、内环上方区［（12.49±9.27）、（6.30±9.27）μm］、外环下方区［（10.95±10.06）、（5.38±10.28）μm］差异有统计学意义，血流密度变化值在中央区（1.34%±1.42%、0.62%±1.08%）、内环颞区（1.55%±2.10%、0.52%±1.90%）、外环颞区（1.02%±1.54%、0.29%±1.50%）差异有统计学意义（P<0.05）；1个月时两组间脉络膜厚度变化值除内环鼻区、外环上方区、内环下方区外，差异均有统计学意义（P<0.05），血流密度变化值的差异仅在中央（1.51%±1.32%、-0.50%±1.93%）和内环颞区（1.80%±1.82%、0.54%±2.38%）具有统计学意义（P<0.05）；术后3个月，两组间脉络膜各区域的厚度及血流密度变化值的差异均无统计学意义（P>0.05）。相关性分析显示，术后1周、3个月时黄斑中心凹下脉络膜厚度与术前相比的变化值及术后各时间点中央区血流密度与术前相比的变化值，均与术前脉络膜血流密度呈负相关（P<0.05），与术前脉络膜厚度无明显相关性（P>0.05）。 结论： ICL植入术后早期，高度近视眼患者的脉络膜厚度和血流密度增加幅度较超高度近视眼更为显著，至术后3个月时恢复至基线水平。ICL植入术对近视眼患者的眼底微环境具有暂时性影响，该影响与术前脉络膜血流状态相关。.
目的： 观察有晶状体眼植入式Collamer透镜（ICL）植入术对近视眼患者脉络膜厚度及血流密度的影响。 方法： 前瞻性队列研究。连续收集2021年6月至2023年5月在青岛大学附属医院眼科确诊为屈光不正并行ICL植入术的患者。根据患者术前近视等效球镜度数是否大于10.00 D，分为高度近视眼（HM）组和超高度近视眼（SHM）组。所有患者均于术前及术后1周、1个月、3个月行相干光层析成像术、相干光层析血管成像术及其他眼科常规检查如视力、眼压、验光等。 结果： 共纳入患者42例（84只眼），年龄（25.27±3.18）岁，男性11例，女性31例。其中HM组20例，SHM组22例。患者术后1周、1个月的脉络膜厚度和血流密度均较术前显著增高（P<0.05），术后3个月恢复至术前水平［术前及术后1周、1个月和3个月，黄斑中心凹下脉络膜厚度分别为（169.49±61.57）、（180.16±66.61）（186.69±63.32）、（169.58±60.82）μm；中央区脉络膜血流密度分别为60.03%±1.60%、61.04%±1.17%、60.42%±1.81%、60.22%±1.57%］。术后1周和1个月，HM组各方向脉络膜厚度及血流密度变化值高于SHM组，1周时两组间脉络膜厚度变化值在内环颞区［（12.20±10.79）、（6.71±9.89）μm］、内环上方区［（12.49±9.27）、（6.30±9.27）μm］、外环下方区［（10.95±10.06）、（5.38±10.28）μm］差异有统计学意义，血流密度变化值在中央区（1.34%±1.42%、0.62%±1.08%）、内环颞区（1.55%±2.10%、0.52%±1.90%）、外环颞区（1.02%±1.54%、0.29%±1.50%）差异有统计学意义（P<0.05）；1个月时两组间脉络膜厚度变化值除内环鼻区、外环上方区、内环下方区外，差异均有统计学意义（P<0.05），血流密度变化值的差异仅在中央（1.51%±1.32%、-0.50%±1.93%）和内环颞区（1.80%±1.82%、0.54%±2.38%）具有统计学意义（P<0.05）；术后3个月，两组间脉络膜各区域的厚度及血流密度变化值的差异均无统计学意义（P>0.05）。相关性分析显示，术后1周、3个月时黄斑中心凹下脉络膜厚度与术前相比的变化值及术后各时间点中央区血流密度与术前相比的变化值，均与术前脉络膜血流密度呈负相关（P<0.05），与术前脉络膜厚度无明显相关性（P>0.05）。 结论： ICL植入术后早期，高度近视眼患者的脉络膜厚度和血流密度增加幅度较超高度近视眼更为显著，至术后3个月时恢复至基线水平。ICL植入术对近视眼患者的眼底微环境具有暂时性影响，该影响与术前脉络膜血流状态相关。.
摘要：
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