Abstract：
3D printing has revolutionized bone tissue engineering (BTE) by enabling the fabrication of patient- or defect-specific scaffolds to enhance bone regeneration. The superior biocompatibility, customizable bioactivity, and biodegradability have enabled calcium phosphate (CaP) to gain significance as a bone graft material. 3D-printed (3DP) CaP scaffolds allow precise drug delivery due to their porous structure, adaptable structure-property relationship, dynamic chemistry, and controlled dissolution. The effectiveness of conventional scaffold-based drug delivery is hampered by initial burst release and drug loss. This review summarizes different multifunctional drug delivery approaches explored in controlling drug release, including polymer coatings, formulation integration, microporous scaffold design, chemical crosslinking, and direct extrusion printing for BTE applications. The review also outlines perspectives and future challenges in drug delivery research, paving the way for next-generation bone repair methodologies.
摘要：
3D打印通过使患者或缺陷特异性支架的制造能够增强骨再生，彻底改变了骨组织工程（BTE）。优越的生物相容性，可定制的生物活性，和生物降解性使磷酸钙（CaP）作为骨移植材料具有重要意义。3D打印（3DP）CaP支架由于其多孔结构而允许精确的药物输送，适应性结构-产权关系，动态化学,和受控溶解。常规的基于支架的药物递送的有效性受到初始突释和药物损失的阻碍。这篇综述总结了在控制药物释放方面探索的不同多功能药物递送方法，包括聚合物涂层，配方整合，微孔支架设计，化学交联,和BTE应用的直接挤出印刷。该综述还概述了药物递送研究的前景和未来挑战，为下一代骨修复方法铺平道路。
