Abstract：
BACKGROUND: A significant body of literature suggests that exercise can reverse cognitive impairment and ameliorate somatic function in patients with Alzheimer\'s disease (AD). Systematic reviews (SRs), a common approach of evidence-based medicine, concentrate on a specific issue of a research area. The objective of this work is to provide an overview of existing evidence on the effects of exercise intervention in AD patients and report related health outcomes by reviewing SRs.
METHODS: SRs on exercise intervention in AD patients were retrieved from the PubMed, the Cochrane Library, CBMdisc, Scopus, Web of Science, Embase (via Ovid), China National Knowledge Infrastructure, and WanFang databases from the time of inception to February 2023. The quality of the SRs was evaluated utilizing the A Measurement Tool to Assess Systematic Review 2 (AMSTAR 2) checklist. The results were reported according to the population-intervention-comparison-outcome (PICO) framework and the corresponding evidence mapping was illustrated in tables and bubble plots.
RESULTS: A total of 26 SRs met the eligibility criteria. In terms of methodological quality, 10 SRs were rated as \"critically low\", 13 SRs were rated as \"low\", and 3 SRs were rated as \"moderate\". Exercise was found to exert a beneficial effect on cognitive function, functional independence, physical function, and neuropsychiatric symptoms in patients with AD.
CONCLUSIONS: Exercise intervention benefits AD patients mainly by improving cognitive function, physical function, functional independence, and neuropsychiatric symptoms. However, due to the low-to-moderate methodology of most SRs included in this analysis, further investigations are required to support our current findings.
METHODS: SRs on exercise intervention in AD patients were retrieved from the PubMed, the Cochrane Library, CBMdisc, Scopus, Web of Science, Embase (via Ovid), China National Knowledge Infrastructure, and WanFang databases from the time of inception to February 2023. The quality of the SRs was evaluated utilizing the A Measurement Tool to Assess Systematic Review 2 (AMSTAR 2) checklist. The results were reported according to the population-intervention-comparison-outcome (PICO) framework and the corresponding evidence mapping was illustrated in tables and bubble plots.
RESULTS: A total of 26 SRs met the eligibility criteria. In terms of methodological quality, 10 SRs were rated as \"critically low\", 13 SRs were rated as \"low\", and 3 SRs were rated as \"moderate\". Exercise was found to exert a beneficial effect on cognitive function, functional independence, physical function, and neuropsychiatric symptoms in patients with AD.
CONCLUSIONS: Exercise intervention benefits AD patients mainly by improving cognitive function, physical function, functional independence, and neuropsychiatric symptoms. However, due to the low-to-moderate methodology of most SRs included in this analysis, further investigations are required to support our current findings.
摘要：
背景：大量文献表明，运动可以逆转阿尔茨海默病（AD）患者的认知障碍并改善躯体功能。系统评价(SRs)，一种常见的循证医学方法，专注于研究领域的特定问题。这项工作的目的是提供关于运动干预对AD患者影响的现有证据的概述，并通过回顾SRs报告相关的健康结果。
方法：从PubMed检索AD患者运动干预的SRs，Cochrane图书馆,CBMdisc,Scopus,WebofScience,Embase（通过Ovid），中国国家知识基础设施，和万方数据库从成立到2023年2月。使用A测量工具评估系统评价2（AMSTAR2）清单评估SR的质量。根据人口干预比较结果（PICO）框架报告结果，并在表格和气泡图中说明了相应的证据映射。
结果：共有26个SR符合资格标准。在方法质量方面，10个SR被评为“极低”，13个SR被评为“低”，3个SR被评为“中等”。运动被发现对认知功能产生有益的影响，功能独立，物理功能，AD患者的神经精神症状。
结论：运动干预主要通过改善认知功能使AD患者受益。物理功能，功能独立，神经精神症状.然而,由于本分析中包含的大多数SR的低到中等的方法，我们需要进一步的调查来支持我们目前的调查结果。
方法：从PubMed检索AD患者运动干预的SRs，Cochrane图书馆,CBMdisc,Scopus,WebofScience,Embase（通过Ovid），中国国家知识基础设施，和万方数据库从成立到2023年2月。使用A测量工具评估系统评价2（AMSTAR2）清单评估SR的质量。根据人口干预比较结果（PICO）框架报告结果，并在表格和气泡图中说明了相应的证据映射。
结果：共有26个SR符合资格标准。在方法质量方面，10个SR被评为“极低”，13个SR被评为“低”，3个SR被评为“中等”。运动被发现对认知功能产生有益的影响，功能独立，物理功能，AD患者的神经精神症状。
结论：运动干预主要通过改善认知功能使AD患者受益。物理功能，功能独立，神经精神症状.然而,由于本分析中包含的大多数SR的低到中等的方法，我们需要进一步的调查来支持我们目前的调查结果。
