介体与 RNA 聚合酶 II 相互作用的核受体控制的 IDR 依赖性机制。
关键词: CDK8 kinase module MED26 Mediator complex RNA polymerase II CTD activation eukaryotic transcription nuclear receptors transcription regulation
Mesh : RNA Polymerase II / metabolism genetics Mediator Complex / metabolism genetics chemistry Humans Protein Binding Cryoelectron Microscopy Cyclin-Dependent Kinase 8 / metabolism genetics Animals Intrinsically Disordered Proteins / metabolism genetics chemistry Binding Sites Receptors, Cytoplasmic and Nuclear / metabolism genetics HEK293 Cells Protein Interaction Domains and Motifs
来 源:
DOI:10.1016/j.molcel.2024.06.006
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