Abstract：
Health problems associated with aging are a major public health concern for the future. Aging is a complex process with wide intervariability among individuals. Therefore, there is a need for innovative public health strategies that target factors associated with aging and the development of tools to assess the effectiveness of these strategies accurately. Novel approaches to measure biological age, such as epigenetic clocks, have become relevant. These clocks use non-sequential variable information from the genome and employ mathematical algorithms to estimate biological age based on DNA methylation levels. Therefore, in the present study, we comprehensively review the current status of the epigenetic clocks and their associations across the human phenome. We emphasize the potential utility of these tools in an epidemiological context, particularly in evaluating the impact of public health interventions focused on promoting healthy aging. Our review describes associations between epigenetic clocks and multiple traits across the life and health span. Additionally, we highlighted the evolution of studies beyond mere associations to establish causal mechanisms between epigenetic age and disease. We explored the application of epigenetic clocks to measure the efficacy of interventions focusing on rejuvenation.
摘要：
与衰老相关的健康问题是未来的主要公共卫生问题。衰老是一个复杂的过程，个体之间存在广泛的互变性。因此,有必要针对与老龄化相关的因素制定创新的公共卫生策略，并开发准确评估这些策略有效性的工具。测量生物年龄的新方法，比如表观遗传时钟，变得相关。这些时钟使用来自基因组的非连续可变信息，并采用数学算法根据DNA甲基化水平估计生物年龄。因此,在本研究中，我们全面回顾了表观遗传时钟的现状及其在人类表型组中的关联.我们强调这些工具在流行病学背景下的潜在效用，特别是在评估以促进健康老龄化为重点的公共卫生干预措施的影响方面。我们的评论描述了表观遗传时钟与整个生命和健康时期的多种特征之间的关联。此外,我们强调了研究的进展，而不仅仅是建立表观遗传年龄和疾病之间的因果机制。我们探索了表观遗传时钟在测量以恢复活力为重点的干预措施功效中的应用。
