Abstract：
Schizophrenia (SZ) and bipolar disorder (BD) are characterized by major symptomatic, cognitive, and neuroanatomical changes. Recent studies have used optical coherence tomography (OCT) to investigate retinal changes in SZ and BD, but their unique and shared changes require further evaluation. Articles were identified using PubMed and Google Scholar. 39 studies met the inclusion criteria. Diagnostic groups were proband (SZ/BD combined), SZ, BD, and healthy control (HC) eyes. Meta-analyses utilized fixed and random effects models when appropriate, and publication bias was corrected using trim-and-fill analysis (\"meta\" package in R). Results are reported as standardized mean differences with 95% CIs. Data from 3145 patient eyes (1956 SZ, 1189 BD) and 3135 HC eyes were included. Studies identified thinning of the peripapillary retinal nerve fiber layer (pRNFL, overall and in 2 subregions), m-Retina (overall and all subregions), mGCL-IPL, mIPL, and mRPE in SZ patients. BD showed thinning of the pRNFL (overall and in each subregion), pGCC, and macular Retina (in 5 subregions), but no changes in thickness or volume for the total retina. Neither SZ nor BD patients demonstrated significant changes in the fovea, mRNFL, mGCL, mGCC, mINL, mOPL, mONL, or choroid thicknesses. Moderating effects of age, illness duration, and smoking on retinal structures were identified. This meta-analysis builds upon previous literature in this field by incorporating recent OCT studies and examining both peripapillary and macular retinal regions with respect to psychotic disorders. Overall, this meta-analysis demonstrated both peripapillary and macular structural retinal abnormalities in people with SZ or BD compared with HCs.
摘要：
精神分裂症（SZ）和双相情感障碍（BD）的特点是主要的症状，认知，和神经解剖学的改变.最近的研究已经使用光学相干断层扫描（OCT）来研究SZ和BD的视网膜变化，但他们的独特和共同的变化需要进一步评估。文章是使用PubMed和GoogleScholar识别的。39项研究符合纳入标准。诊断组为先证者（SZ/BD联合），SZ,BD,和健康的控制（HC）眼睛。荟萃分析在适当的时候利用固定和随机效应模型，使用修剪和填充分析(R中的“meta”包)纠正发表偏倚。结果报告为95%CI的标准化平均差异。来自3145例患者眼睛的数据(1956SZ，包括1189BD）和3135HC眼。研究确定了乳头周围视网膜神经纤维层的变薄（pRNFL，总体和两个次区域)，m-Retina（整体和所有子区域），mGCL-IPL,mIPL,SZ患者的mRPE。BD显示pRNFL变薄(总体和每个子区域)，pGCC,和黄斑视网膜（在5个亚区），但总视网膜的厚度或体积没有变化。SZ和BD患者均未表现出中央凹的显着变化，mRNFL,mGCL,mGCC,mINL,MOPL,MONL,或脉络膜厚度。年龄的调节作用，疾病持续时间,并确定在视网膜结构上吸烟。该荟萃分析建立在该领域先前文献的基础上，结合了最近的OCT研究，并检查了有关精神病的乳头周围和黄斑视网膜区域。总的来说,这项荟萃分析显示，与HCs相比，SZ或BD患者的乳头周围和黄斑结构性视网膜异常。
