Abstract：
Variations in the epidemiology, clinical presentation, and disease course in atopic dermatitis (AD) patients with Skin of Color (SOC) compared with white counterparts have been reported. In this study, we evaluated the capability of a new imaging device (SkinCam) in quantifying skin texture changes in diverse patients, presenting with AD or xerosis, after using a prebiotic skincare routine over 10 weeks. A total of 39 subjects from diverse racial/ethnic backgrounds, aged 3 to 76 years old, with Fitzpatrick skin phototypes I to VI, presenting with mild AD and moderate to severe xerosis, were enrolled in the study. All subjects used a prebiotic cleanser on its own for 2 weeks, followed by a prebiotic moisturizer in conjunction for an additional 8 weeks. Standardized images of the subjects\' legs were taken with SkinCam at several time points (baseline, week 2, and week 10), and analyzed for skin texture parameters. Our results demonstrate that both skin texture irregularity and skin color patterns significantly improve over time with a prebiotic skincare regimen in AD (n=12) and xerosis (n=24) subjects. Interestingly, image analyses showed more improvement over time in xerosis and AD SOC patients (n=18, Fitzpatrick IV-VI). Lastly, skin texture analyses from SkinCam imaging correlated with clinical assessments, showing significant improvement by prebiotic skincare regimen in all subjects by week 10. In summary, our results demonstrate that the SkinCam imaging device has the capability to effectively monitor skin texture parameters over time in both AD and xerosis patients with lightly and darkly pigmented skin. J Drugs Dermatol. 2024;23(7):557-563. doi:10.36849/JDD.8371.
摘要：
流行病学的变化，临床表现,与白人相比，特应性皮炎（AD）患者的彩色皮肤（SOC）和病程已有报道。在这项研究中,我们评估了一种新型成像设备（SkinCam）在量化不同患者皮肤纹理变化方面的能力，表现为AD或干燥症，在使用益生元护肤常规超过10周后。共有39名来自不同种族/族裔背景的受试者,3至76岁，菲茨帕特里克皮肤照型I到VI，表现为轻度AD和中度至重度干燥症，参加了这项研究。所有受试者单独使用益生元清洁剂2周，然后用益生元保湿剂再服用8周。在几个时间点使用SkinCam拍摄受试者腿的标准化图像(基线，第2周和第10周)，并分析了皮肤纹理参数。我们的结果表明，随着时间的推移，在AD（n=12）和干燥病（n=24）受试者中，采用益生元护肤方案，皮肤纹理不规则和皮肤颜色模式均显着改善。有趣的是,图像分析显示干燥症和ADSOC患者随着时间的推移有更多改善(n=18,FitzpatrickIV-VI).最后,来自SkinCam成像的皮肤纹理分析与临床评估相关，到第10周时，所有受试者的益生元护肤方案均显示出显着改善。总之,我们的研究结果表明，SkinCam成像设备能够有效地监测皮肤质地参数随时间的变化，同时监测患有轻度和深色皮肤的AD和干症患者的皮肤质地参数。J药物Dermatol。2024；23（7）：557–563。doi:10.36849/JDD.8371。
