Abstract：
We present a two-stage model for the study of chronic hind limb ischemia in rats. In the area of ischemia, sclerotic changes with atrophic rhabdomyocytes and reduced vascularization were revealed. CD31 expression in the endothelium increased proportionally to the number of vessels in the ischemic zone, and at the same time, focal expression of βIII-tubulin was detected in the newly formed nerve fibers. These histological features are equivalent to the development of peripheral arterial disease in humans, which allows using our model in the search for new therapeutic strategies.
摘要：
我们提出了一个用于研究大鼠慢性后肢缺血的两阶段模型。在缺血区域，显示出萎缩性横纹肌细胞的硬化变化和血管形成减少。内皮中CD31的表达与缺血区的血管数量成比例增加，同时,在新形成的神经纤维中检测到βIII-微管蛋白的局灶性表达。这些组织学特征相当于人类外周动脉疾病的发展，这允许使用我们的模型来寻找新的治疗策略。
