Abstract：
Spatial learning, memory, and reactivity of the hypothalamic-pituitary-adrenocortical system (HPA axis) were studied in adult male rats, whose mothers during pregnancy were subjected to acute moderate normobaric hypoxia, or repeated injections of buspirone, an agonist of type 1A serotonergic receptors (5HT1A), or their combination. Prenatal treatment with buspirone in rats with prenatal hypoxia impaired learning ability during the first day of 5-day training. A decrease in the effectiveness of long-term memory in comparison with short-term memory was revealed in two groups of rats: prenatal treatment with buspirone in combination with hypoxia and injection of physiological saline without hypoxia. The effectiveness of long-term memory and the level of corticosterone in response to stress did not differ between the groups, which can indicate adaptation of the 5HT1A receptor and the HPA axis to the prenatal buspirone and normobaric hypoxia during ontogeny.
摘要：
空间学习,记忆,在成年雄性大鼠中研究了下丘脑-垂体-肾上腺皮质系统（HPA轴）的反应性，其母亲在怀孕期间遭受急性中度常压缺氧，或者反复注射丁螺环酮,1A型血清素能受体（5HT1A）的激动剂，或他们的组合。在5天训练的第一天，对产前缺氧损害学习能力的大鼠进行产前丁螺环酮治疗。在两组大鼠中，长期记忆的有效性与短期记忆相比有所下降：产前给予丁螺环酮联合缺氧和注射无缺氧的生理盐水。长期记忆的有效性和皮质酮对压力的反应在两组之间没有差异，这可以表明5HT1A受体和HPA轴在个体发育过程中对产前丁螺环酮和常压缺氧的适应。
