Abstract：
Given that glioma cells tend to infiltrate and migrate along WM tracts, leading to demyelination and axonal injuries, Diffusion Tensor Imaging (DTI) emerged as a promising tool for identifying major \"high-risk areas\" of recurrence within the peritumoral brain zone (PBZ) or at a distance throughout the adjacents white matter tracts. Of our systematic review is to answer the following research question: In patients with brain tumor, is DTI able to recognizes within the peri-tumoral brain zone (PBZ) areas more prone to local (near the surgical cavity) or remote recurrence compared to the conventional imaging techniques?. We conducted a comprehensive literature search to identify relevant studies in line with the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) guidelines. 15 papers were deemed compatible with our research question and included. To enhance the paper\'s readability, we have categorized our findings into two distinct groups: the first delves into the role of DTI in detecting PBZ sub-regions of infiltration and local recurrences (n = 8), while the second group explores the feasibility of DTI in detecting white matter tract infiltration and remote recurrences (n = 7). DTI values and, within a broader framework, radiomics investigations can provide precise, voxel-by-voxel insights into the state of PBZ and recurrences. Better defining the regions at risk for potential recurrence within the PBZ and along WM bundles will allow targeted therapy.
摘要：
鉴于神经胶质瘤细胞倾向于沿着WM束浸润和迁移，导致脱髓鞘和轴突损伤,扩散张量成像（DTI）是一种有前途的工具，可用于识别肿瘤周围脑区（PBZ）或在整个相邻白质区域的一定距离内复发的主要“高风险区域”。我们的系统评价是回答以下研究问题：在脑肿瘤患者中，与常规成像技术相比，DTI是否能够识别肿瘤周围脑区（PBZ）区域更容易发生局部（靠近手术腔）或远程复发？我们进行了全面的文献检索，以确定符合PRISMA-P（系统评价和荟萃分析方案的首选报告项目）指南的相关研究。15篇论文被认为与我们的研究问题相符，并包括在内。为了提高论文的可读性，我们将我们的发现分为两个不同的组：第一个研究DTI在检测PBZ亚区域浸润和局部复发中的作用（n=8），第二组探讨了DTI检测白质道浸润和远程复发的可行性（n=7）。DTI值和,在更广泛的框架内，影像组学调查可以提供精确的，逐个体素洞察PBZ的状态和复发。更好地定义PBZ内和沿着WM束有潜在复发风险的区域将允许靶向治疗。
