PDF(Pubmed)
Abstract：
Obesity and obesity-related metabolic disorders are global epidemics that occur when there is chronic energy intake exceeding energy expenditure. Growing evidence suggests that healthy dietary patterns not only decrease the risk of obesity but also influence the composition and function of the gut microbiota. Numerous studies manifest that the development of obesity is associated with gut microbiota. One promising supplementation strategy is modulating gut microbiota composition by dietary patterns to combat obesity. In this review, we discuss the changes of gut microbiota in obesity and obesity-related metabolic disorders, with a particular emphasis on the impact of dietary components on gut microbiota and how common food patterns can intervene in gut microbiota to prevent obesity. While there is promise in intervening with the gut microbiota to combat obesity through the regulation of dietary patterns, numerous key questions remain unanswered. In this review, we critically review the associations between dietary patterns, gut microbes, and obesity, aiming to contribute to the further development and application of dietary patterns against obesity in humans.
摘要：
肥胖和肥胖相关的代谢紊乱是全球流行病，当长期能量摄入超过能量消耗时发生。越来越多的证据表明，健康的饮食模式不仅可以降低肥胖的风险，还可以影响肠道微生物群的组成和功能。大量研究表明，肥胖的发展与肠道微生物群有关。一种有前途的补充策略是通过饮食模式调节肠道微生物群组成以对抗肥胖。在这次审查中,我们讨论了肥胖和肥胖相关代谢紊乱中肠道菌群的变化，特别强调饮食成分对肠道微生物群的影响，以及常见的食物模式如何干预肠道微生物群以预防肥胖。虽然有希望通过调节饮食模式来干预肠道微生物群以对抗肥胖，许多关键问题仍未得到回答。在这次审查中,我们批判性地回顾了饮食模式之间的关联，肠道微生物,肥胖，旨在为人类肥胖饮食模式的进一步发展和应用做出贡献。
