PDF(Pubmed)
Abstract：
UNASSIGNED: A combination of genetic and environmental factors contribute to the highly common, complex, and varied endocrine condition known as polycystic ovary syndrome (PCOS) in women. PCOS primarily affects women between the ages of 15 and 35 who are in the early to late stages of pregnancy. Thus, this study aimed to evaluate the serum levels of irisin, subfatin, and adropin in PCOS with and without obesity compared to the control group.
UNASSIGNED: The present cross-sectional study was conducted in 2022 at Al-Nahrain University/Department of Chemistry (Baghdad, Iraq). The serum levels of irisin, subfatin, and adropin were measured with the enzyme-linked immunosorbent assay (ELISA) method. Body mass index, lipid profile, insulin, fasting glucose, follicle-stimulating hormone, and luteinizing hormone levels were also evaluated. The data were analyzed using one-way analysis of variance (ANOVA) by GraphPad Prism software version 8.0.2. A P<0.05 was considered statistically significant.
UNASSIGNED: The study population comprised PCOS patients (n=90, divided into 45 obese and 45 normal weight) and healthy women (n=30). According to the results, the serum levels of irisin were significantly higher (P<0.001) in obese and normal-weight PCOS patients than controls. While adropin and subfatin were significantly lower in PCOS than controls (P<0.001). Moreover, there are higher levels of serum insulin, fasting glucose, and luteinizing hormone in PCOS women than in healthy women.
UNASSIGNED: According to the findings, PCOS patients had a higher level of irisin than the controls. In addition, decreased subfatin and adropin levels were observed in PCOS patients compared with healthy women. Further research is required to confirm these results in the future.
UNASSIGNED: The present cross-sectional study was conducted in 2022 at Al-Nahrain University/Department of Chemistry (Baghdad, Iraq). The serum levels of irisin, subfatin, and adropin were measured with the enzyme-linked immunosorbent assay (ELISA) method. Body mass index, lipid profile, insulin, fasting glucose, follicle-stimulating hormone, and luteinizing hormone levels were also evaluated. The data were analyzed using one-way analysis of variance (ANOVA) by GraphPad Prism software version 8.0.2. A P<0.05 was considered statistically significant.
UNASSIGNED: The study population comprised PCOS patients (n=90, divided into 45 obese and 45 normal weight) and healthy women (n=30). According to the results, the serum levels of irisin were significantly higher (P<0.001) in obese and normal-weight PCOS patients than controls. While adropin and subfatin were significantly lower in PCOS than controls (P<0.001). Moreover, there are higher levels of serum insulin, fasting glucose, and luteinizing hormone in PCOS women than in healthy women.
UNASSIGNED: According to the findings, PCOS patients had a higher level of irisin than the controls. In addition, decreased subfatin and adropin levels were observed in PCOS patients compared with healthy women. Further research is required to confirm these results in the future.
摘要：
■遗传和环境因素的结合导致了高度常见的，复杂，以及各种内分泌疾病，称为多囊卵巢综合征（PCOS）。PCOS主要影响15至35岁的妇女，她们处于怀孕的早期到晚期。因此，这项研究旨在评估血清irisin的水平，subfatin,与对照组相比，有肥胖和无肥胖的PCOS和adropin。
■本横断面研究于2022年在Al-Nahrain大学/化学系（巴格达，伊拉克)。irisin的血清水平,subfatin,用酶联免疫吸附试验(ELISA)方法测定adropin。身体质量指数,血脂谱,胰岛素，空腹血糖,促卵泡激素,和黄体生成素水平也进行了评估。通过GraphPadPrism软件8.0.2版使用单向方差分析(ANOVA)分析数据。P<0.05被认为具有统计学意义。
■研究人群包括PCOS患者（n=90，分为45名肥胖和45名正常体重）和健康女性（n=30）。根据结果,肥胖和体重正常的PCOS患者血清irisin水平明显高于对照组(P<0.001).PCOS患者的adropin和subfatin显著低于对照组(P<0.001)。此外，血清胰岛素水平较高，空腹血糖,和黄体生成素在PCOS妇女比健康妇女。
■根据调查结果，PCOS患者的irisin水平高于对照组。此外,与健康女性相比,PCOS患者的亚脂肪素和adropin水平降低.将来需要进一步的研究来证实这些结果。
■本横断面研究于2022年在Al-Nahrain大学/化学系（巴格达，伊拉克)。irisin的血清水平,subfatin,用酶联免疫吸附试验(ELISA)方法测定adropin。身体质量指数,血脂谱,胰岛素，空腹血糖,促卵泡激素,和黄体生成素水平也进行了评估。通过GraphPadPrism软件8.0.2版使用单向方差分析(ANOVA)分析数据。P<0.05被认为具有统计学意义。
■研究人群包括PCOS患者（n=90，分为45名肥胖和45名正常体重）和健康女性（n=30）。根据结果,肥胖和体重正常的PCOS患者血清irisin水平明显高于对照组(P<0.001).PCOS患者的adropin和subfatin显著低于对照组(P<0.001)。此外，血清胰岛素水平较高，空腹血糖,和黄体生成素在PCOS妇女比健康妇女。
■根据调查结果，PCOS患者的irisin水平高于对照组。此外,与健康女性相比,PCOS患者的亚脂肪素和adropin水平降低.将来需要进一步的研究来证实这些结果。
